{"id":4095,"date":"2025-02-17T20:32:41","date_gmt":"2025-02-18T01:32:41","guid":{"rendered":"https:\/\/martemyanovlab.com\/?page_id=4095"},"modified":"2026-02-25T12:22:00","modified_gmt":"2026-02-25T17:22:00","slug":"publications","status":"publish","type":"page","link":"https:\/\/martemyanovlab.com\/index.php\/publications\/","title":{"rendered":"Publications"},"content":{"rendered":"\n

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The following articles were published by Kirill Martemyanov, his lab members and his collaborators. To move from the citations below to full articles in the National Library of Medicine’s PubMed archive<\/a>, click on each paper’s title in blue. You can also search annual publications by clicking directly on the years below.<\/p><\/h3>\n\n\n\n

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Martemyanov Publications by Year:<\/strong><\/h3>\n\n\n\n

2026<\/a> | 2025<\/a> | 2024<\/a> | 2023<\/a> | 2022<\/a> | 2021<\/a> | 2020<\/a> | 2019<\/a> | 2018<\/a> | 2017<\/a> | 2016<\/a> | 2015<\/a> | 2014<\/a> | 2013<\/a> | 2012<\/a> | 2011<\/a> | 2010<\/a> | 2009<\/a> | 2008<\/a> | 2007<\/a> | 2006<\/a><\/h3>\n\n\n\n

2026<\/h3>\n\n\n\n
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1. <\/strong>Laboute T, Zucca S, Sial OK, Sharma M, Brunori G, Singh S, Nageswar KV, Peng H, Rader C, Becker JA, Le Merrer J, Singh AK, Martemyanov KA<\/strong>. <\/span><\/h3>

Targeting mGlyR with nanobodies for depression.<\/a><\/h3><\/a><\/span>Nature Communications<\/em><\/span><\/em> 2026 Jan 26;17(1):831. doi: 10.1038\/s41467-026-68339-x. <\/span>

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2025<\/h3>\n\n\n\n
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10. <\/strong>Ludlam WG, Dom\u00ednguez-Carral J, Schteinschnaider A, Martemyanov KA<\/strong>, Ortigoza-Escobar JD. <\/span><\/h3>

Novel\u00a0GNAO1<\/em>\u00a0variant in \u03b1-helical domain reveals alternative mechanism of disease. <\/a><\/h3>

Genes and Diseases<\/em><\/span> <\/span>2025 Nov 21;13(2):101714. doi: 10.1016\/j.gendis.2025.101714.<\/span><\/h3><\/td><\/tr>

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9. <\/strong>Shishikura K, Li J, Chen Y, McKnight NR, Keeley TP, Bustin KA, Barr EW, Chilkamari SR, Ayub M, Kim SW, Lin Z, Hu RM, Hicks K, Wang X, O’Rourke DM, Martin Bollinger J Jr, Binder ZA, Parsons WH, Martemyanov KA<\/strong>, Liu A, Matthews ML. <\/span><\/h3>

Hydralazine inhibits cysteamine dioxygenase to treat preeclampsia and senesce glioblastoma.<\/a><\/h3>

Science Advances<\/em><\/span> <\/span>2025 Oct 17;11(42):eadx7687. doi: 10.1126\/sciadv.adx7687<\/span><\/h3><\/td><\/tr>

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8. <\/strong>Ren Q, Wang J, Idikuda V, Zhang S, Shin J, Ludlam WG, Real Hernandez LM, Zdancewicz S, Kreutzberger AJB, Chang H, Kiessling V, Tamm LK, Jomaa A, Levental I, Martemyanov KA<\/strong>, Chanda B, Bao H.<\/h3>

DeFrND: detergent-free reconstitution into native nanodiscs with designer membrane scaffold peptides. <\/a>
Nature Communications<\/em><\/span><\/em> 2025 Aug 26;16(1):7973. doi: 10.1038\/s41467-025-63275-8. <\/span><\/h3><\/td><\/tr>

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7. <\/strong>Li X, Winters ND, Pandey S, Lankford C, Stoveken H, Smith E, Chang CT, Zucca S, Scampavia L, Spicer T, Martemyanov KA.<\/strong>
Homeostatic scaling of dynorphin signaling by a non-canonical opioid receptor<\/a>
Nature Communications<\/em><\/span><\/em> 2025 Jul 23;16(1):6786. doi: 10.1038\/s41467-025-62133-x.<\/span><\/h3><\/td><\/tr>

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6. <\/strong>Aguado C, Fajardo-Serrano A, Alfaro-Ruiz R, Mart\u00ednez-Poyato ML, Moreno-Mart\u00ednez AE, Garc\u00eda-Madrona S, Rold\u00e1n-Sastre A, Alonso-G\u00f3mez P, Fern\u00e1ndez M, Puertas-Avenda\u00f1o R, Shigemoto R, Martemyanov KA,<\/strong> Lujan R<\/span>
Developmental regulation of GABAB<\/sub> receptors and downstream molecules in the mouse brain<\/a>
Histology and Histopathology<\/em><\/span><\/em> 2025 Jul 18:18970. doi: 10.14670\/HH-18-970.<\/span><\/h3><\/td><\/tr>

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5. <\/strong>Wang T, Dom\u00ednguez-Carral J, Ludlam WG, Segarra MJ, Marti MF, Bruining H, Martemyanov KA,<\/strong> Linkenkaer-Hansen K, Ortigoza-Escobar JD<\/span>
Neuronal oscillatory imbalances in GNAO1-related disorders associated with disease severity<\/a>
Epilespia<\/em><\/span><\/em> 2025 Jun 27. doi: 10.1111\/epi.18513.<\/span><\/h3><\/td><\/tr>

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4. <\/strong>Dore R, Chang C, Decl\u00e8ve A, Brunori G, Ludlam WG, Huang A, Movahedinia M, Damseh N, Anwar I, Mehrjardi MYV, Ny A, Khorrami M, Kheirollahi M, Frederiksen H, Eghbal F, Mirjalili MR, Dehghani M, Karimiani EG, Oreshkov S, Alves C, Striano P, Suri M, Martinez-Agosto J, Ansar M, Zahid M, Akram S, Ansar M, Nelson S; Undiagnosed Diseases Network; Antonarakis SE, Houlden H, Copmans D, Martemyanov KA,<\/strong> Maroofian R<\/span>
ELFN1 deficiency: The mechanistic basis and phenotypic spectrum of a neurodevelopmental disorder with epilepsy<\/a>
Genetics in Medecine<\/em><\/span><\/em> 2025 Jun 23;27(9):101506.<\/span><\/h3><\/td><\/tr>

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3. <\/strong>Zhao C, Cao Y, Ibrahim N, Wang Y, Martemyanov KA.<\/strong>
Efficient in vivo labeling of endogenous proteins with SMART delineates retina cellular and synaptic organization<\/a>
Nature Communications<\/em><\/em><\/span><\/em> 2025  Apr 22;16(1):3768.<\/span><\/h3><\/td><\/tr>

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2. <\/strong>Zucca S, Brunori G, Dunn H, Lankford C, Sutton L, Flores BA, Maza N, Sial O, Crynen G, Luj\u00e1n R, Martemyanov KA.<\/strong>
Trans-synaptic modulation of cholinergic circuits tunes opioid reinforcement<\/a>
Proceedings of the National Academy of Sciences USA<\/em><\/span><\/em> 2025 Mar 25;122(12):e2409325122.<\/span><\/h3><\/td><\/tr>

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1. <\/strong>Dunn H, Dhaliwal SK, Chang CT, Martemyanov KA.<\/strong>
Distinct autoregulatory roles of ELFN1 intracellular and extracellular domains on membrane trafficking, synaptic localization, and dimerization<\/a>
Journal of Biological Chemistry<\/span><\/em> (2025) 301(1):108073.<\/span><\/h3><\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n

2024<\/h3>\n\n\n\n
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5. <\/strong>Luo H, Anderson A, Masuho I, Fernandez de Velasco EM, Birnbaumer L, Martemyanov KA, <\/strong>Wickman K.
Receptor-dependent influence of R7 RGS proteins on neuronal GIRK channel signaling dynamics<\/a>
<\/span><\/em>Progress in Neurobiology<\/em><\/span> (2024) 102686.<\/span><\/span><\/span><\/h3><\/td><\/tr>

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4. <\/strong>Yun Y, Jeong H, Laboute T, Martemyanov KA,<\/strong> Lee HH.
Cryo-EM structure of human class C orphan GPCR GPR179 involved in visual processing<\/a>
Nature Communications<\/span><\/em> (2024) 15:8299.<\/span><\/h3><\/td><\/tr>

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3. <\/strong>Knight K, Krumm B, Kapolka N, Ludlam WG, Cui M, Manu S, Prytkova I, Obarow EG, Lefevre TJ, Wei W, Ma N, Huang XP, Fay JF, Vaidehi N, Smrcka AV, Slesinger PA, Logothetis DE, <\/span>Martemyanov KA.<\/strong> Roth, BL, Dohlman HG. <\/strong>
A neurodevelopmental disorder mutation locks G proteins in the transitory pre-activated state<\/a>
Nature Communication<\/span><\/em> (2024) 15(1):6643.<\/span><\/h3><\/td><\/tr>

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2. <\/strong>Ludlam WG, Soliani L, Dom\u00ednguez-Carral J, Cordelli DM, Marchiani V, Gorr\u00eda-Redondo N, Aguilera-Albesa S, Martemyanov KA,<\/strong> Ortigoza-Escobar JD
Diverse faces of GNAO1: mild forms in epilepsy and autism<\/a>
Journal of Neurology<\/span><\/em> (2024) 271(7), 3777\u20133781.<\/span><\/h3><\/td><\/tr>

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1. <\/strong>Nelic D, Chetverikov N, Hochmalov\u00e1 M, Diaz C, Dole\u017eal V, Boulos J, Jakub\u00edk J, Martemyanov KA,<\/strong> Janou\u0161kov\u00e1-Rand\u00e1kov\u00e1 A.
Agonist-selective activation of individual G-proteins by muscarinic receptors<\/a>
Scientific Reports<\/span><\/em> (2024) 14(1):9652.<\/span><\/h3><\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n

2023<\/h3>\n\n\n\n
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5. <\/strong>Dom\u00ednguez-Carral J, Ludlam WG, Junyent Segarra M, Fornaguera Marti M, Balsells S, Muchart J, \u010cokoli\u0107 Petrovi\u0107 D, Espinoza I, Ortigoza-Escobar JD, Martemyanov KA, <\/strong>GNAO1-Study Group.
Severity of GNAO1-Related Disorder Correlates with Changes in G-Protein Function<\/a>
<\/span><\/em>Annals of Neurology<\/span> (2023) 26758.<\/span><\/span><\/span><\/h3><\/td><\/tr>

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4. <\/strong>Masuho I, Kise R, Gainza P, Von Moo E, Li X, Tany R, Wakasugi-Masuho H, Correia BE, Martemyanov KA. <\/strong>
Rules and mechanisms governing G protein coupling selectivity of GPCRs<\/a>
Cell Rep<\/span><\/em> (2023) 113173.<\/span><\/h3><\/td><\/tr>

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3. <\/strong>Patil DN, Pantalone S, Cao Y, Laboute T, Novick SJ, Singh S, Savino S, Faravelli S, Magnani F, Griffin PR, Singh AK, Forneris F, Martemyanov KA. <\/strong>
Structure of the photoreceptor synaptic assembly of the extracellular matrix protein pikachurin with the orphan receptor GPR179<\/a>
Sci Signal<\/span><\/em> (2023) 16:eadd9539.<\/span><\/h3><\/td><\/tr>

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2. <\/strong>Park J-C, Luebbers A, Dao M, Semeano A, Nguyen AM, Papakonstantinou MP, Broselid S, Yano H, Martemyanov KA, <\/strong>Garcia-Marcos M.
Fine-tuning GPCR-mediated neuromodulation by biasing signaling through different G protein subunits<\/a>
Moll Cell<\/span><\/em> (2023) 83:2540-2558.<\/span><\/h3><\/td><\/tr>

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1. <\/strong>Laboute T, Zucca S, Holcomb M, Patil DN, Garza C, Wheatley BA, Roy RN, Forli S, Martemyanov KA<\/strong>.
O<\/a>rphan receptor GPR158 serves as a metabotropic glycine receptor: mGly<\/a>R<\/a>
Science<\/span><\/em> (2023) 379:1352-1358.<\/span><\/h3><\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n

2022<\/h3>\n\n\n\n
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9. <\/strong>Ives AN, Dunn HA, Afsari HS, Seckler HDS, Foroutan MJ, Chavez E, Melani RD, Fellers RT, LeDuc RD, Thomas PM, Martemyanov KA<\/strong>, Kelleher NL, Vafabakhsh R.
Middle-Down Mass Spectrometry Reveals Activity-Modifying Phosphorylation Barcode in a Class C G Protein-Coupled Receptor<\/a>
J Am Chem Soc.<\/u><\/em><\/span><\/em> (2022) 144(50):23104-23114.<\/span><\/h3><\/td><\/tr>

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8. <\/strong>Campla C, Bocchero U, Strickland R, Nellissery J, Advani J, Ignatova I, Srivastava D, Aponte A, Wang Y, Gumerson J, Martemyanov KA<\/strong>, Artemyev N, Pahlberg J, Swaroop A.
<\/a>Frmpd1 facilitates trafficking of G-protein transducin and modulates synaptic function in rod photoreceptors of mammalian retina<\/a>
eNeuro.<\/u><\/em><\/span><\/em> (2022) 30:ENEURO.0348-22.2022.<\/span><\/h3><\/td><\/tr>

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7. <\/strong>Maza N, Wang D, Kowalski C, Stoveken H, Dao M, Sial O, Giles A, Grill, Martemyanov KA<\/strong>.
<\/a>Ptchd1 mediates opioid tolerance via cholesterol-dependent effects on \u03bc-opioid receptor trafficking<\/a>
Nat Neurosci.<\/u><\/em><\/span><\/em> (2022) 25:1179-1190.<\/span><\/h3><\/td><\/tr>

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6. <\/strong>Cao Y, Fajardo D, Guerrero-Given D, Samuel MA, Ohtsuka T, Boye SE, Kamasawa N, Martemyanov KA<\/strong>.
<\/a>Post-developmental plasticity of the primary rod pathway allows restoration of visually guided behaviors<\/a>
Curr Biol.<\/u><\/em><\/span><\/em> (2022) S0960-9822 01460-9.<\/span><\/h3><\/td><\/tr>

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5. <\/strong>Beier C, Bocchero U, Levy L, Martemyanov KA<\/strong>, Hattar S, Pahlberg J.
<\/a>Divergent outer retinal circuits drive image and non-image visual behaviors<\/a>
Cell Rep<\/u><\/em><\/span><\/em> (2022) 28;39:111003.<\/span><\/h3><\/td><\/tr>

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4. <\/strong>Marwari S, Kowalski C, Martemyanov KA<\/strong>.
<\/a>Exploring pharmacological inhibition of G q\/11 as an analgesic strategy<\/a>
Br J Pharmacol<\/u><\/em><\/span><\/em> (2022) 10.1111\/bph.15935. <\/span><\/h3><\/td><\/tr>

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3. <\/strong>Hopkins B, Masuho I, Ren D, Iyamu I, Lv W, Malik N, Martemyanov KA<\/strong>, Schiltz G, Miller R.
<\/a>Effects of Small Molecule Ligands on ACKR3 Receptors<\/a>
Mol Pharmacol<\/u><\/em><\/span><\/em> (2022) 10.1124\/molpharm.121.000295<\/span>.<\/h3><\/td><\/tr>

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2. <\/strong>Muntean BS, Marwari S, Li X, Sloan DC, Young BD, Wohlschlegel JA, Martemyanov KA<\/strong>.
Members of the KCTD family are major regulators of cAMP signaling.<\/a>
Proceedings of the National Academy of Sciences USA<\/span><\/em> (2022) 119:e2119237119. <\/span><\/h3><\/td><\/tr>

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1. <\/strong>Patil DN, Singh S, Laboute T, Strutzenberg TS, Qiu X, Wu D, Novick SJ, Robinson CV, Griffin PR, Hunt JF, Izard T, Singh AK, Martemyanov KA<\/strong>. 
Cryo-EM structure of human GPR158 receptor coupled to the RGS7-G\u03b25 signaling complex<\/span><\/a>
Science<\/span><\/em> (2021) 375:86-91.<\/h3><\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n

2021<\/h3>\n\n\n\n
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11.<\/strong> Wang Y, Cao Y, Hays CL, Laboute T, Ray TA, Guerrero-Given D, Ahuja AS, Patil D, Rivero O, Kamasawa N, Kay JN, Thoreson WB, Martemyanov KA<\/strong>. 
Adhesion GPCR Latrophilin 3 regulates synaptic function of cone photoreceptors in a trans-synaptic manner<\/span><\/a>
Proceedings of the National Academy of Sciences USA<\/span> <\/em>(2021) 118:e2106694118. <\/h3><\/td><\/tr>

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10.<\/strong> Wang D., Dao M., Muntean B.S., Giles A.C., Martemyanov K.A<\/strong>., Grill B.
Genetic modeling of GNAO1 disorder delineates mechanisms of G\u03b1o dysfunction<\/span><\/a>
Human Molecular Genetics<\/span><\/em> (2021) in press.<\/h3><\/td><\/tr>

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9.<\/strong> Shao, Z., Masuho, I., Tumber, A., Maynes, J.T., Tavares, E., Ali, A., Hewson, S., Schulze, A., Kannu, P., Martemyanov, K.A<\/strong>, Vincent A.
Extended phenotyping and functional validation facilitate diagnosis of a complex patient harboring genetic variants in MCCC1<\/em> and GNB5<\/em> causing overlapping phenotypes<\/span><\/a>
Genes (Basel)<\/span><\/em> (2021) 12:1352.<\/h3><\/td><\/tr>

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8.<\/strong> Moo EV., Harps\u00f8e K., Hauser A.S., Masuho I., Br\u00e4uner-Osborne H., Gloriam D.E., Martemyanov K.A<\/strong>.
<\/a>Ligand-directed bias of G protein signaling at the dopamine D2 receptor<\/a><\/span>
Cell Chemical Biology<\/span><\/em> (2021) <\/span>in press.<\/span><\/h3><\/td><\/tr>

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7.<\/strong> Stoveken H.M., Fernandez-Vega V., Muntean B.S., Patil D.N., Shumate J., Bannister T.D., Scampavia L., Spicer T.P., Martemyanov K.A<\/strong>.
Identification of potential modulators of the RGS7\/G\u03b25\/R7BP complex<\/a><\/span>
SLAS Discovery<\/span> <\/span><\/em>(2021) 26:1177-1188. <\/span><\/h3><\/td><\/tr>

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6. Martemyanov K.A.<\/strong>
Mechanisms of G\u03b2\u03b3 release upon GPCR activation<\/a><\/span>
Trends in Biochemical Sciences<\/span><\/em> <\/strong>(2021) <\/span>46:703-704. <\/span><\/h3><\/td><\/tr>

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5.<\/strong> Masuho I., Skamangas N.K., Muntean B.S., Martemyanov K.A.<\/strong>
Diversity of the G\u03b2\u03b3 complexes defines spatial and temporal bias of GPCR signaling<\/span><\/a>
<\/span><\/em>

Cell Systems<\/span><\/em><\/em> (2021) 12:324-337.e5. <\/p><\/h3><\/td><\/tr>

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4. <\/strong>Muntean B.S., Masuho I., Dao M., Sutton L.P., Zucca S., Iwamoto H., Patil D.N., Wang D., Birnbaumer L., Blakely R.D., Grill B., Martemyanov K.A.<\/strong>
G\u03b1o is a major determinant of cAMP signaling in the pathophysiology of movement disorders<\/span><\/a>
Cell Reports<\/em><\/u> (2021) 34:108718. <\/p><\/h3><\/td><\/tr>

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3. <\/strong>Dao M., Stoveken H.M., Cao Y., Martemyanov K.A.<\/strong>
The role of orphan receptor GPR139 in neuropsychiatric behavior<\/span><\/a>
Neuropsychopharmacology<\/em><\/u> (2021) in press. <\/p><\/h3><\/td><\/tr>

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2. <\/strong>Melis C., Beauvais G., Muntean B.S., Cirnaru M.D., Otrimski G., Creus-Muncunill J., Martemyanov K.A.<\/strong>, Gonzalez-Alegre P., Ehrlich M.E.
Striatal dopamine induced ERK phosphorylation is altered in mouse models of monogenic dystonia<\/span><\/a>
Movement Disorders<\/em><\/u> (2021) 36:1147-1157. <\/p><\/h3><\/td><\/tr>

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1.<\/strong> Sutton L.P., Khalatyan N., Savas J.N., Martemyanov K.A.<\/strong>
Striatal RGS7 regulates depression-related behaviors and stress-induced reinstatement of cocaine conditioned place preference<\/span><\/a>
eNeuro.<\/em><\/u> (2021) 8:ENEURO.0365-20.2020. <\/p><\/h3><\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n

2020<\/h3>\n\n\n\n
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8.<\/strong> Masuho I., Balaji S., Muntean B.S., Skamangas N.K., Chavali S., Tesmer J.J.G., Babu M.M., Martemyanov K.A.<\/strong> 
A global map of G protein signaling regulation by RGS proteins<\/span><\/a>
Cell<\/u><\/em> (2020)  183:503-521.e19. <\/p><\/h3><\/td><\/tr>

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7. <\/strong>Bartoszek A., Moo E.V., Binienda A., Fabisiak A., Krajewska J.B., Mosi\u0144ska P., Niewinna K., Tarasiuk A., Martemyanov K.A.<\/strong>, Salaga M., Fichna J.
Free fatty acid receptors as new potential therapeutic target in inflammatory bowel diseases<\/span><\/a>  
Pharmaceutical Research<\/em><\/u> (2020) 152:104604. <\/p><\/h3><\/td><\/tr>

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6. <\/strong>Anderson A., Masuho I., Marron Fernandez de Velasco E., Nakano A., Birnbaumer L., Martemyanov K.A.<\/strong>, Wickman K.
GPCR-dependent biasing of GIRK channel signaling dynamics by RGS6 in mouse sinoatrial nodal cells<\/span><\/a> 
Proceedings of the National Academy of Sciences USA<\/u><\/em> (2020) 117:14522-14531.  <\/p><\/h3><\/td><\/tr>

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5. <\/strong>Stoveken H.M, Zucca S., Masuho I., Grill B., Martemyanov K.A.<\/strong> 
The orphan receptor GPR139 signals via Gq\/11 to oppose opioid effects<\/span><\/a>  
Journal of Biological Chemistry<\/em><\/u> (2020) 295:10822-10830. <\/p><\/h3><\/td><\/tr>

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4. <\/strong>Schultz-Rogers L., Masuho I., Pinto e Vairo F., Schmitz C.T., Schwab T.L., Clark K.J., Gunderson L., Pichurin P.N., Wierenga K., Martemyanov K.A.<\/strong>, Klee E.W.
Haploinsufficiency as a disease mechanism in GNB1-associated neurodevelopmental disorder<\/span><\/a>
Molecular Genetics and Genomic Medicine<\/em><\/u> (2020) 8:e1477.  <\/p><\/h3><\/td><\/tr>

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3. <\/strong>Cao Y., Wang Y., Dunn H.A., Orlandi C., Shultz N., Kamasawa N., Fitzpatrick D., Li W., Zeitz C., Hauswirth W., Martemyanov K.A.<\/strong>
Interplay between cell adhesion molecules governs synaptic wiring of cone photoreceptors<\/span><\/a>   
Proceedings of the National Academy of Sciences USA<\/u><\/em> (2020) 117:23914-23924. <\/p><\/h3><\/td><\/tr>

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2.<\/strong> Xu L., Bolch S.N., Santiago C.P., Dyka F.M., Akil O., Lobanova E., Wang Y., Martemyanov K.A.<\/strong>, Hauswirth W.W., Smith W.C., Handa J.T., Blackshaw S., Ash J.D., Dinculescu A.
Clarin-1 expression in adult mouse and human retina highlights a role of M\u00fcller Glia in Usher Syndrome<\/span><\/a>
The Journal of Pathology<\/u><\/em> (2020) 250:195-204.<\/p><\/h3><\/td><\/tr>

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1. <\/strong>Masuho, I., Skamangas, N.K., Martemyanov, K.A<\/strong>.
Live cell optical assay for precise characterization of receptors coupling to G\u03b112<\/span><\/a>
Basic & Clinical Pharmacology & Toxicology<\/em><\/u> (2020) 126 Suppl 6:88-95. <\/p><\/h3><\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n

2019<\/h3>\n\n\n\n
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12.<\/strong> Doyle T., Muntean B., Ejendal K., Hayes M., Soto-Velasquez M., Martemyanov K.A.<\/strong>, Dessauer C., Hu C.D., Watts V.
Identification of novel adenylyl cyclase 5 (AC5) signaling networks in D1 and D2 medium spiny neurons using bimolecular fluorescence complementation screening<\/span><\/a>
Cell<\/u><\/em> (2019) 8:1468.<\/p><\/h3><\/td><\/tr>

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11. <\/strong>Green M.V., Pengo T., Raybuck J.D., Naqvi T., McMullan H.M, Hawkinson J.E., Fernandez de Velasco E.M., Muntean B.S., Martemyanov K.A.<\/strong>, Satterfield R., Young S.M., Thayer S.A.
Automated live-cell imaging of synapses in rat and human neuronal cultures<\/span><\/a>
Frontiers in Cellular Neuroscience<\/u><\/em> (2019) 13:467.<\/p><\/h3><\/td><\/tr>

\"\"<\/td>

10. <\/strong>Sutton L.P., Muntean B.S., Ostrovskaya O., Zucca S., Dao M., Orlandi C., Song C., Xie K., Martemyanov K.A.<\/strong>
NF1-cAMP signaling dissociates cell type specific contributions of striatal medium spiny neurons to reward valuation and motor control<\/span><\/a>
PLOS Biology<\/u><\/em> (2019) 17:e3000477. <\/p><\/h3><\/td><\/tr>

\"\"<\/td>

9.<\/strong> Cirnaru, M.D., Melis, C., Fanutza, T., Naphade, S., Tshilenge, K.N., Muntean, B.S., Martemyanov, K.A.<\/strong>, Plotkin, J.L., Ellerby, L.M., Ehrlich, M.E.
Nuclear receptor Nr4a1 regulates striatal striosome development and dopamine D1 receptor signaling<\/span>
<\/a>eNeuro<\/u><\/em> (2019) 6:ENEURO.0305-19.2019. <\/span><\/p><\/h3><\/td><\/tr>

\"\"<\/td>

8. <\/strong>Muntean, B.S., Dao, M.T., Martemyanov, K.A.<\/strong>
Allostatic changes in cAMP system drive opioid induced adaptation in striatal dopamine signaling<\/span><\/a> 
Cell Reports<\/u><\/em> (2019) 29:946-960.e2. <\/p><\/h3><\/td><\/tr>

\"\"<\/td>

7. <\/strong>Wang, D., Stoveken, H.M., Zucca, S., Dao, M., Orlandi, C., Song, C., Masuho, I., Johnston, C., Opperman, K.J., Giles, A.C., Gill, M.S., Lundquist, E.A., Grill, B., Martemyanov, K.A.<\/strong>
Genetic behavioral screen identifies an orphan anti-opioid system<\/span><\/a>
Science<\/u><\/em> (2019) 365:1267-1273. <\/p><\/h3><\/td><\/tr>

\"\"<\/td>

6. <\/strong>Dunn, H.A., Orlandi, C., Martemyanov, K.A.<\/strong>
Beyond the ligand: extracellular and transcellular GPCR complexes in physiology and pharmacology<\/span><\/a>
Pharmacological Reviews<\/u><\/em> (2019) 71:503-519. <\/p><\/h3><\/td><\/tr>

\"\"<\/td>

5.<\/strong> Dunn, H.A., Zucca, S., Dao, M., Orlandi, C., Martemyanov, K.A.<\/strong>
ELFN2 is a postsynaptic cell adhesion molecule with essential roles in controlling group III mGluRs in the brain and neuropsychiatric behavior<\/span><\/a>
Molecular Psychiatry<\/u><\/em> (2019) 24:1902-1919.  <\/p><\/h3><\/td><\/tr>

\"\"<\/td>

4.<\/strong> Song, C., Orlandi, C., Sutton, L.P., Martemyanov, K.A.<\/strong>
The signaling proteins GPR158 and RGS7 modulate excitability of L2\/3 pyramidal neurons and control A-type potassium channel in the prelimbic cortex<\/span><\/a>
Journal of Biological Chemistry<\/u> <\/em>(2019) <\/em>294:13145-13157. <\/p><\/h3><\/td><\/tr>

\"\"<\/td>

3.<\/strong> Xu, Z.X., Tan J.W., Hill, C.J., Xu, H., Ostrovskaya, O., Martemyanov, K.A.<\/strong>, Xu, B.
Caspase-2 promotes AMPA receptor internalization and cognitive flexibility via mTORC2-AKT-GSK3b signaling<\/span><\/a>
Nature Communications<\/u><\/em> (2019) 10:3622. <\/p><\/h3><\/td><\/tr>

\"\"<\/td>

2.<\/strong> Itakura, T., Webster, A., Chintala, S.K., Wang, Y., Gonzalez, J.M. Jr., Tan, J.C., Vranka, J.A., Acott, T., Craft, C.M., Sibug Saber, M.E., Jeong, S., Stamer, W.D., Martemyanov, K.A.<\/strong>, Fini, M.E.
GPR158 in the visual system: homeostatic role in regulation of intraocular pressure<\/span><\/a>
Journal of Ocular Pharmacology and Therapeutics<\/u><\/em> (2019) 35:203-215.<\/p><\/h3><\/td><\/tr>

\"\"<\/td>

1.<\/strong> Orlandi, C., Sutton, L.P., Muntean, B.S., Song, C., Martemyanov, K.A.<\/strong>
Homeostatic cAMP regulation by the RGS7 complex controls depression-related behaviors<\/span><\/a> 
Neuropsychopharmacology<\/u><\/em> (2019) 44:642-653. <\/p><\/h3><\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n

2018<\/h3>\n\n\n\n
\"\"<\/td>

19.<\/strong> Patil, D.N., Rangarajan, E.S., Novick, S.J., Pascal, B.D., Kojetin, D.J., Griffin, P.R., Izard, T., Martemyanov, K.A<\/strong>.
Structural organization of a major neuronal G protein regulator, the RGS7-G\u03b25-R7BP complex<\/span><\/a>
eLife<\/span><\/em> (2018) 7:e42150. <\/p><\/h3><\/td><\/tr>

\"\"<\/td>

18.<\/strong> Ostrovskaya, Ol., Orlandi, C., Fajardo-Serrano, A., Young, S.M. Jr., Lujan, R., Martemyanov, K.A<\/strong>.
Inhibitory signaling to ion channels in hippocampal neurons is differentially regulated by alternative macromolecular complexes of RGS7<\/span><\/a>
The Journal of Neuroscience<\/span><\/em> (2018) 38:10002-10015. <\/p><\/h3><\/td><\/tr>

\"\"<\/td>

17.<\/strong> Condomitti, G., Wierda, K.D., Schroeder, A., Rubio, S.E., Vennekens, K.M., Orlandi C., Martemyanov, K.A.<\/strong>, Gounko, N.V., Savas J.N., de Wit, J.
An input-specific orphan receptor GPR158-HSPG interaction organizes hippocampal mossy fiber-CA3 synapses<\/span><\/a>
Neuron<\/span><\/em> (2018) 100:201-215.e9. <\/p><\/h3><\/td><\/tr>

\"\"<\/td>

16. <\/strong>Orlandi, C., Omori, Y., Wang, Y., Cao, Y., Ueno, A., Roux, M.J., Condomitti, G., de Wit, J., Kanagawa, M., Furukawa, T., Martemyanov, K.A.<\/strong>
Transsynaptic binding of orphan receptor GPR179 to dystroglycan-pikachurin complex is essential for the synaptic organization of photoreceptors<\/a>
 Cell Reports<\/span><\/em> (2018) 25:130-145.e5. <\/p><\/h3><\/td><\/tr>

\"\"<\/td>

15. <\/strong>Song, C., Anderson, G.R., Sutton, L.P., Dao, M., Martemyanov, K.A.<\/strong>
Selective role of RGS9-2 in regulating retrograde synaptic signaling of indirect pathway medium spiny neurons in dorsal striatum<\/span><\/a>
The<\/span> Journal of Neuroscience<\/span><\/em> (2018) 38:7120-7131. <\/p><\/h3><\/td><\/tr>

\"\"<\/td>

14. <\/strong>Masuho, I., Chavali, S., Muntean, B.S., Skamangas, N.K., Simonyan, K., Patil, D. N., Kramer, G.M., Ozelius, L., Babu, M.M., Martemyanov, K.A.<\/strong>
Molecular deconvolution platform to establish disease mechanisms by surveying GPCR signaling<\/span><\/a>
Cell Reports<\/span><\/em> (2018) 24:557-568.e5. <\/p><\/h3><\/td><\/tr>

\"\"<\/td>

13. <\/strong>Dunn, H.A., Patil, D.N., Cao, Y., Orlandi, C., Martemyanov, K.A.<\/strong>
Synaptic adhesion protein ELFN1 is a selective allosteric modulator of group III metabotropic glutamate receptors in trans<\/em><\/span><\/a>
Proceedings of the National Academy of Sciences USA<\/span><\/em> (2018) 115:5022-5027. <\/p><\/h3><\/td><\/tr>

\"\"<\/td>

12.<\/strong> Gulati, S., Masuho, I., Orban, T., Cai, Y., Pardon, E., Martemyanov, K.A.<\/strong>, Kiser, P.D., Stewart, P.L., Ford, C.P., Steyaert, J., and Palczewski, K.
Targeting G protein-coupled receptor signaling at the G protein level with a selective nanobody inhibitor<\/span><\/a>
Nature Communications<\/span><\/em> (2018) 9:1996. <\/p><\/h3><\/td><\/tr>

\"\"<\/td>

11. Martemyanov, K.A.<\/strong>, Garcia-Marcos, M.
Making useful gadgets with miniaturized G proteins<\/span><\/a>
Journal of Biological Chemistry<\/span><\/em> (2018) 293:7474-7475. <\/p><\/h3><\/td><\/tr>

\"\"<\/td>

10.<\/strong> Kulkarni, K., Xie, X., Fernandez de Velasco, EM., Anderson, A., Martemyanov, K.A.,<\/strong> Wickman, K., Tolkacheva, E.G.
The influences of the M2R-GIRK4-RGS6 dependent parasympathetic pathway on electrophysiological properties of the mouse heart<\/span><\/a>
PLos One<\/span><\/em> (2018) 13:e0193798. <\/p><\/h3><\/td><\/tr>

\"\"<\/td>

9.<\/strong> Muntean, B.S., Patil, D.N., Madoux, F., Fossetta, J., Scampavia, L., Spicer, T.P., Martemyanov, K.A.<\/strong>
A high-throughput time-resolved fluorescence energy transfer assay to screen for modulators of RGS7\/G\u03b25\/R7BP complex<\/span><\/a>
Assay and Drug Development Technologies<\/span><\/em> (2018) 16:150-161. <\/p><\/h3><\/td><\/tr>

\"\"<\/td>

8. <\/strong>Marcott, P.F., Gong, S., Donthamsetti, P., Grinnell, S.G., Nelson, M.N., Newman, A.H., Birnbaumer, L., Martemyanov, K.A., <\/strong>Javitch, J.A., Ford, C.P.
Regional heterogeneity of D2-receptor signaling in the dorsal striatum and nucleus accumbens<\/span><\/a>
Neuron<\/span><\/em> (2018) 98:575-587.e4. <\/p><\/h3><\/td><\/tr>

\"\"<\/td>

7. <\/strong>Spicer, T.P., Hubbs, C., Vaissiere, T., Collia, D., Rojas, C., Kilinc, M., Vick, K., Madoux, F., Baillargeon, P., Shumate, J., Martemyanov, K.A.<\/strong>, Page, D.T., Puthanveettil, S., Hodder, P., Davis, R., Miller, C.A., Scampavia, L., Rumbaugh, G.
Improved scalability of neuron-based phenotypic screening assays for therapeutic discovery in neuropsychiatric disorders<\/span><\/a>
Molecular Neuropsychiatry<\/span><\/em> (2018) 3:141-150. <\/p><\/h3><\/td><\/tr>

\"\"<\/td>

6.<\/strong> Sarria, I., Cao, Y., Wang, Y., Ingram, N.T., Orland,i C., Kamasawa, N., Kolesnikov, A.V., Pahlberg, J., Kefalov, V.J., Sampath, A.P., Martemyanov, K.A<\/strong>.
LRIT1 modulates adaptive changes in synaptic communication of cone photoreceptors<\/span><\/a>
Cell Reports<\/span><\/em> (2018) 22:3562-3573. <\/p><\/h3><\/td><\/tr>

\"\"<\/td>

5.<\/strong> Sutton, L.P., Orlandi, C., Song, C., Oh, W.C., Muntean, B.S., Xie, K., Filippini, A., Xie, X., Satterfield, R., Yaeger, J.D.W., Renner, K.J., Young, S.M., Xu, B., Kwon, H., Martemyanov, K.A<\/strong>.
Orphan receptor GPR158 controls stress-induced depression<\/span><\/a>
eLife<\/span><\/em> (2018) 7:e33273. <\/p><\/h3><\/td><\/tr>

\"\"<\/td>

4.<\/strong> Anderson, A., Kulkarni, K., Marron Fernandez de Velasco, E., Carlblom, N., Xia, Z., Nakano, A., Martemyanov, K.A.,<\/strong> Tolkacheva, E.G., Wickman, K.
Expression and relevance of the G protein-gated K+ channel in the mouse ventricle<\/span><\/a>
Scientific Reports<\/span><\/em> (2018) 8:1192. <\/p><\/h3><\/td><\/tr>

\"\"<\/td>

3.<\/strong> Qutob, N., Masuho, I., Alon, M., Emmanuel, R., Cohen, I., Di Pizio, A., Madore, J., Elkahloun, A., Ziv, T., Levy, R., Gartner, J.J., Hill, V.K., Lin, J.C., Hevroni, Y., Greenberg, P., Brodezki, A., Rosenberg, S.A., Koslo, M., Hayward, N.K., Admon, A., Niv MY, Scolyer RA, Martemyanov, K.A.<\/strong>, Samuels Y.
RGS7 is recurrently mutated in melanoma and promotes migration and invasion of human cancer cells<\/span><\/a>
Scientific Reports<\/span><\/em> (2018) 8:653. <\/p><\/h3><\/td><\/tr>

\"\"<\/td>

2.<\/strong> Hauser, A.S., Chavali, S., Masuho, I., Jahn, L.J., Martemyanov, K.A.<\/strong>, Gloriam, D.E., Babu, M.M.
Pharmacogenomics of GPCR drug targets<\/span><\/a>
Cell<\/span><\/em> (2018) <\/em>172:41-54.e19. <\/p><\/h3><\/td><\/tr>

\"\"<\/td>

1. <\/strong>Muntean, B.S., Zucca, S., MacMullen, C.M., Dao, M.T., Johnston, C., Iwamoto, H., Blakely, R.D., Davis, R.L., Martemyanov, K.A.<\/strong>
Interrogating the spatiotemporal landscape of neuromodulatory GPCR signaling by real-time imaging of cAMP in intact neurons and circuits<\/span><\/a>
Cell Reports<\/span><\/em> (2018) 22:255-268. <\/p><\/h3><\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n

2017<\/h3>\n\n\n\n
\"\"<\/td>

6. <\/strong>Himmelreich, S., Masuho, I., Berry, J.A., MacMullen, C., Skamangas, N.K., Martemyanov, K.A.<\/strong>, Davis, R.L.
Dopamine receptor DAMB signals via Gq to mediate forgetting in Drosophila<\/span><\/a>
Cell Reports<\/span><\/em> (2017) 21:2074-2081. <\/p><\/h3><\/td><\/tr>

\"\"<\/td>

5. Martemyanov, K.A.<\/strong>, Sampath, A.P.
The transduction cascade in retinal ON-Bipolar cells: signal processing and disease<\/span><\/a>
Annual Review of Vision Science<\/span><\/em> (2017) 3:25-51. <\/p><\/h3><\/td><\/tr>

\"\"<\/td>

4. <\/strong>Carmon, K.S., Gong, X., Yi, J., Wu, L., Thomas, A., Moore, C.M., Masuho, I., Timson, D.J., Martemyanov, K.A.<\/strong>, Liu, Q.J.
LGR5 receptor promotes cell-cell adhesion in stem cells and colon cancer cells via the IQGAP1-Rac1 pathway<\/span><\/a>
Journal of Biological Chemistry<\/span><\/em> (2017) 292:14989-15001. <\/p><\/h3><\/td><\/tr>

\"\"<\/td>

3. <\/strong>Neuill\u00e9, M., Cao, Y., Caplette, R., Guerrero-Given, D., Thomas, C., Kamasawa, N., Sahel, J.A., Hamel, C.P., Audo, I., Picaud, S., Martemyanov, K.A.<\/strong>, Zeitz, C. 
LRIT3 Differentially affects connectivity and synaptic transmission of cones to ON- and OFF-Bipolar cells<\/span><\/a>
Investigative Ophthalmology and Visual Science<\/span><\/em> (2017) 58:1768-1778.<\/p><\/h3><\/td><\/tr>

\"\"<\/td>

2. <\/strong>Wang, Y., Fehlhaber, K.E., Sarria, I., Cao, Y., Ingram, N.T., Guerrero-Given, D., Throesch, B., Baldwin, K., Kamasawa, N., Ohtsuka, T., Sampath, A.P., Martemyanov, K.A.<\/strong> 
The auxiliary calcium channel subunit \u03b12\u03b44 is required for axonal elaboration, synaptic transmission, and wiring of rod photoreceptors<\/span><\/a>
Neuron<\/span><\/em> (2017) 93:1359-1374.e6. <\/p><\/h3><\/td><\/tr>

\"\"<\/td>

1.<\/strong> Lohmann, K., Masuho, I., Patil, D.N., Baumann, H., Hebert, E., Steinr\u00fccke, S., Trujillano, D., Skamangas, N.K., Dobricic, V., H\u00fcning, I., Gillessen-Kaesbach, G., Westenberger, A., Savic-Pavicevic, D., M\u00fcnchau, A., Oprea, G., Klein, C., Rolfs, A., Martemyanov, K.A<\/strong>.
Novel GNB1 mutations disrupt assembly and function of G protein heterotrimers and cause global developmental delay in humans<\/a>
Human Molecular Genetics<\/span><\/em> (2017) 26:1078-1086.<\/p><\/h3><\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n

2016<\/h3>\n\n\n\n
\"\"<\/td>

13.<\/strong> Aguado, C., Orlandi, C., Fajaro-Serrano, A., Gil-Minguez, M., Martemyanov, K.A.<\/strong>, Lujan, R.
Cellular and subcellular localization of the RGS7\/G\u03b25\/R7BP complex in the cerebellar cortex<\/span><\/a>
Frontiers in Neuroanatomy<\/span><\/em> (2016) 10:114. <\/p><\/h3><\/td><\/tr>

\"\"<\/td>

12.<\/strong> Xie, K., Colgan, L.A., Dao, M.T., Muntean, B.S., Sutton, L.P., Orlandi, C., Boye, S.L., Boye, S.E., Shih, C.C., Li, Y., Xu, B., Smith, R.G., Yasuda, R., Martemyanov, K.A.<\/strong>
NF1 is a direct protein effector essential for opioid signaling to Ras in the striatum<\/span><\/a>
Current Biology<\/span><\/em> (2016) 26:2992-3003.<\/p><\/h3><\/td><\/tr>

\"\"<\/td>

11. <\/strong>Victoria, N.C., Marron, Fernandez de Velasco, E., Ostrovskaya, O., Metzger, S., Xia, Z., Kotecki, L., Benneyworth, M.A., Zink, A.N., Martemyanov, K.A.<\/strong>, Wickman, K.
G protein-gated K+ channel ablation in forebrain pyramidal neurons selectively impairs fear learning<\/span><\/a>
Biological Psychiatry<\/span><\/em> (2016) 80:796-806. <\/p><\/h3><\/td><\/tr>

\"\"<\/td>

10.<\/strong> Shamseldin, H.E., Masuho, I., Alenizi, A., Alyamani, S., Patil, D.N., Ibrahim, N., Martemyanov, K.A<\/strong>., Alkuraya, F.S.
GNB5 mutation causes a novel neuropsychiatric disorder featuring attention deficit hyperactivity disorder, severely impaired language development and normal cognition<\/span><\/a>
Genome Biology<\/span><\/em> (2016) 17:195. <\/p><\/h3><\/td><\/tr>

\"\"<\/td>

9.<\/strong> Sutton, L.P., Ostrovskaya, O., Dao, M., Xie, K., Orlandi, C., Smith, R., Wee, S., Martemyanov, K.A<\/strong>.
Regulator of G-protein signaling 7 regulates reward behavior by controlling opioid signaling in the striatum<\/span><\/a>
Biological Psychiatry<\/span><\/em> (2016) 80:235-245. <\/p><\/h3><\/td><\/tr>

\"\"<\/td>

8.<\/strong> Chen, Y., Palczewska, G., Masuho, I., Gao, S., Jin, H., Dong, Z., Gieser, L., Brooks, M.J., Kiser, P.D., Kern, T.S., Martemyanov, K.A.<\/strong>, Swaroop, A., Palczewski, K.
Synergistically acting agonists and antagonists of G protein-coupled receptors prevent photoreceptor cell degeneration<\/span><\/a>
Science Signaling<\/span><\/em> (2016) 9:ra74. <\/p><\/h3><\/td><\/tr>

\"\"<\/td>

7.<\/strong> Masuho, I., Fang, M., Geng, C., Zhang, J., Jiang, H., \u00d6zgul, R.K., Y\u0131lmaz, D.Y., Yaln\u0131zo\u011flu, D., Y\u00fcksel, D., Yarrow, A., Myers, A., Burn, S.C., Crotwell, P.L., Padilla-Lopez, S., Dursun, A., Martemyanov, K.A<\/strong>., Kruer, M.C.
Homozygous GNAL mutation associated with familial childhood-onset generalized dystonia<\/span><\/a>
Neurology Genetics<\/span><\/em> (2016) 2:e78. <\/p><\/h3><\/td><\/tr>

\"\"<\/td>

6.<\/strong> Dos Santos, C.O., Masuho, I., da Silva-J\u00fanior, F.P., Barbosa, E.R., Silva, S.M., Borges, V., Ferraz, H.B., Rocha, M.S., Limongi, J.C., Martemyanov, K.A.<\/strong>, de Carvalho Aguiar, P.
Screening of GNAL variants in Brazilian patients with isolated dystonia reveals a novel mutation with partial loss of function<\/span><\/a>
Journal of Neurology<\/span><\/em> (2016) 263:665-668. <\/p><\/h3><\/td><\/tr>

\"\"<\/td>

5.<\/strong> Xu, Y., Orlandi, C., Cao, Y., Yang, S., Choi, C.I., Pagadala, V., Birnbaumer, L., Martemyanov, K.A<\/strong>., Vardi, N.
The TRPM1 channel in ON-bipolar cells is gated by both the \u03b1 and the \u03b2\u03b3 subunits of the G-protein Go<\/span><\/a>
Scientific Reports<\/span><\/em> (2016) 6:20940. <\/p><\/h3><\/td><\/tr>

\"\"<\/td>

4.<\/strong> Tayou, J., Wang, Q., Jang, G.F., Pronin, A.N., Orlandi, C., Martemyanov, K.A<\/strong>., Crabb, J.W., Slepa,k V.Z.
Regulator of G-protein Signaling 7 (RGS7) can exist in a homo-oligomeric form that is regulated by G\u03b1o and R7-binding protein<\/span><\/a><\/a>
Journal of Biological Chemistry<\/span><\/em> (2016) 291:9133-9147.<\/p><\/h3><\/td><\/tr>

\"\"<\/td>

3.<\/strong> Sarria, I., Orlandi, C., McCall, M.A., Gregg, R.G., Martemyanov, K.A.<\/strong>
Intermolecular interaction between anchoring subunits specify subcellular targeting and function of RGS proteins in retina ON-bipolar neurons<\/span><\/a>
The Journal of Neuroscience<\/span><\/em> (2016) 36:2915-2925. <\/p><\/h3><\/td><\/tr>

\"\"<\/td>

2.<\/strong> Muntean, B.S., Martemyanov, K.A.<\/strong>
Association with the plasma membrane Is sufficient for potentiating catalytic activity of regulators of G protein signaling (RGS) proteins of the R7 subfamily<\/span><\/a>
Journal of Biological Chemistry<\/em><\/span> (2016);291:7195-7204. <\/p><\/h3><\/td><\/tr>

\"\"<\/td>

1.<\/strong> Salaga, M., Storr, M., Martemyanov, K.A.<\/strong>, Fichna, J.
RGS proteins as targets in the treatment of intestinal inflammation and visceral pain: New insights and future perspectives<\/span><\/a>
BioEssays<\/span><\/em> (2016) 38:344-354.<\/p><\/h3><\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n

2015<\/h3>\n\n\n\n
\"\"<\/td>

7. <\/strong><\/strong>Masuho, I., Ostrovskaya, O., Kramer, G.M., Jones, C.D., Xie, K., Martemyanov, K.A.<\/strong> <\/strong>
Distinct profiles of functional discrimination among G proteins determine the actions of G protein-coupled receptors<\/span><\/a>
Science Signaling<\/span><\/em> (2015) 8:ra123. <\/p><\/h3><\/td><\/tr>

\"\"
<\/td>

6. <\/strong><\/strong>Xie, K., Masuho, I., Shih, C.C., Cao, Y., Sasaki, K., Lai, C.W., Han, P.L., Ueda, H., Dessauer, C.W., Ehrlich, M.E., Xu, B., Willardson, B.M., Martemyanov, K.A.<\/strong>
<\/strong>Stable G protein-effector complexes in striatal neurons: mechanism of assembly and role in neurotransmitter signaling<\/span><\/a> <\/strong>
Elife<\/span><\/em> (2015) 4:e10451.<\/p><\/h3><\/td><\/tr>

\"\" <\/td>

5. <\/strong><\/strong>Cao, Y., Sarria, I., Fehlhaber, K.E., Kamasawa, N., Orlandi, C., James, K.N., Hazen, J.L., Gardner, M.R., Farzan, M., Lee, A., Baker, S., Baldwin, K., Sampath, A.P., Martemyanov, K.A<\/strong>
<\/strong>Mechanism for selective synaptic wiring of rod photoreceptors into the retinal circuitry and its role in vision<\/span><\/a>
Neuron<\/span><\/em> (2015) 87:1248-1260. <\/p><\/h3><\/td><\/tr>

\"\"<\/td>

4.<\/strong> <\/strong>Masuho, I., Martemyanov, K.A.<\/strong><\/strong>, Lambert, N.A.
Monitoring G protein activation in cells with BRET<\/span><\/a>
Methods in Molecular Biology<\/span><\/em> (2015) 1335:107-113. <\/p><\/h3><\/td><\/tr>

\"\"<\/td>

3. <\/strong><\/strong>Neuill\u00e9, M., Morgans, C.W., Cao, Y., Orhan, E., Michiels, C., Sahel, J.A., Audo, I., Duvoisin, R.M., Martemyanov, K.A.<\/strong><\/strong>, Zeitz, C.
LRIT3 is essential to localize TRPM1 to the dendritic tips of depolarizing bipolar cells and may play a role in cone synapse formation<\/span><\/a>
European Journal of Neuroscience<\/span><\/em> (2015) 42:1966-1975.<\/p><\/h3><\/td><\/tr>

\"\"<\/td>

2. <\/strong><\/strong>Sarria, I., Pahlberg, J., Cao, Y., Kolesnikov, A.V., Kefalov, V.J., Sampath, A.P., Martemyanov, K.A<\/strong>.
<\/strong>Sensitivity and kinetics of signal transmission at the first visual synapse differentially impact visually-guided behavior<\/span><\/a>
eLife<\/span><\/em> (2015) 4:e06358. <\/p><\/h3><\/td><\/tr>

\"\"<\/td>

1. <\/strong><\/strong>Orlandi, C., Xie, K., Masuho, I., Fajardo-Serrano, A., Lujan, R., Martemyanov, K.A.<\/strong>
Orphan receptor GPR158 is an allosteric modulator of regulator of G protein signaling 7 (RGS7) catalytic activity with essential role in dictating its expression and localization in the brain<\/span><\/a>
Journal of Biological Chemistry<\/span><\/em> (2015) 290:13622-13639. <\/p><\/h3><\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n

2014<\/h3>\n\n\n\n
\"\"<\/td>

5. Martemyanov, K.A.<\/strong>
G protein signaling in the retina and beyond: the Cogan lecture<\/span><\/a>
Investigative Ophthalmology and Visual Science<\/span><\/em> (2014) 55:8201-07.<\/p><\/h3><\/td><\/tr>

\"\"<\/td>

4. <\/strong>Ray, T.A., Heath, K.M., Hasan, N., Noel, J.M., Samuels, I.S., Martemyanov, K.A.<\/strong>, Peachey, N.S., McCall, M.A., Gregg, R.G.
GPR179 Is required for high sensitivity of the mGluR6 signaling cascade in depolarizing bipolar cells<\/span><\/a>
The Journal of Neuroscience<\/span><\/em> (2014) 34:6334-6343. <\/p><\/h3><\/td><\/tr>

\"\"<\/td>

3. <\/strong>Ostrovskaya, O., Xie, K., Masuho, I., Fajardo-Serrano, A., Lujan, R., Wickman, K., Martemyanov, K.A<\/strong>.
RGS7\/G\u03b25\/R7BP complex regulates synaptic plasticity and memory by modulating hippocampal GABABR-GIRK signaling<\/span><\/a>
eLife<\/span><\/em> (2014) 3:e02053. <\/p><\/h3><\/td><\/tr>

\"\"<\/td>

2.<\/strong> Kumar, K.R., Lohmann, K., Masuho, I., Miyamoto, R., Ferbert, A., Lohnau, T., Kasten, M., Hagenah, J., Br\u00fcggemann, N., Graf, J., M\u00fcnchau, A., Kostic, V.S., Sue, C.M., Domingo, A.R., Rosales, R.L., Lee, L.V., Freimann, K., Westenberger, A., Mukai, Y., Kawarai, T., Kaj,i R., Klein, C., Martemyanov, K.A.<\/strong>, Schmidt, A.
Mutations in GNAL: a novel cause of craniocervical dystonia<\/span><\/a>
JAMA Neurology<\/span><\/em> (2014) 71:490-494. <\/p><\/h3><\/td><\/tr>

\"\"<\/td>

1. <\/strong>Wydeven, N., Posokhova, E., Xia, Z., Martemyanov, K.A<\/strong>., Wickman, K.
RGS6, but not RGS4, is the dominant regulator of G protein signaling (RGS) modulator of the parasympathetic regulation of mouse heart rate<\/span><\/a>
Journal of Biological Chemistry<\/span><\/em> (2014) 289:2440-9. <\/p><\/h3><\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n

2013<\/h3>\n\n\n\n
\"\"<\/td>

5. <\/strong>Posokhova, E., NG, D., Opel, A., Masuho, I., Tinker, A., Biesecker, L.G., Wickman, K., Martemyanov, K.A<\/strong>.
Essential role of the m2R-RGS6-IKACh pathway in controlling intrinsic heart rate variability<\/span><\/a>
PLoS One<\/span><\/em> (2013) 8:e76973. <\/p><\/h3><\/td><\/tr>

\"\"<\/td>

4. <\/strong>Orlandi, C., Cao, Y., Martemyanov, K.A.<\/strong> 
Orphan receptor GPR179 forms macromolecular complexes with components of metabotropic signaling cascade in retina ON-bipolar neurons<\/span><\/a>
Investigative Ophthalmology and Visual Science<\/span><\/em> (2013) 54:7153-7161. <\/p><\/h3><\/td><\/tr>

\"\"<\/td>

3. <\/strong>Masuho, I., Xie, K., Martemyanov, K.A.<\/strong> 
Macromolecular composition dictates receptor and G protein selectivity of regulator of G protein signaling (RGS) 7 and 9-2 protein complexes in living cells<\/span><\/a>
Journal of Biological Chemistry<\/span><\/em> (2013) 288:25129-25142. <\/p><\/h3><\/td><\/tr>

\"\"<\/td>

2.<\/strong> Fajardo-Serrano, A., Wydeven, N., Young, D., Watanabe, M., Shigemoto, R., Martemyanov, K.A<\/strong>., Wickman K., Lujan, R.
Association of Rgs7\/G\u03b25 complexes with Girk channels and GABAB receptors in hippocampal CA1 pyramidal neurons<\/span><\/a>
Hippocampus<\/span><\/em> (2013) 23:1231-1245.<\/p><\/h3><\/td><\/tr>

\"\"<\/td>

1.<\/strong> Fuchs, T., Saunders-Pullman, R., Masuho, I., San Luciano, M., Raymond, D., Factor, S., Lang, A.E., Liang, T-W, Trosch, R.M., White, S., Ainehsazan, E., Herve, D., Sharma, N., Ehrlich, M.E., Martemyanov, K.A<\/strong>., Bressma, S.B., Ozelius, L.J.
Mutations in GNAL cause primary torsion dystonia<\/span><\/a>
Nature Genetics<\/span><\/em> (2013) 45:88-92.<\/p><\/h3><\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n

2012<\/h3>\n\n\n\n
\"\"<\/td>

5. <\/strong>Xie, K., Masuho, I., Brand, C., Dessauer, C.W., Martemyanov, K.A<\/strong>.
The complex of G protein regulator RGS9-2 and G\u03b25 controls sensitization and signaling kinetics of type 5 adenylyl cyclase in the striatum<\/span><\/a>
Science Signaling<\/span><\/em> (2012) 5:ra63. <\/p><\/h3><\/td><\/tr>

\"\"<\/td>

4. <\/strong>Orlandi, C., Posokhova, E., Masuho, I., Ray, T.A., Hasan, N., Gregg, R.G., Martemyanov, K.A.<\/strong>
GPR158\/179 regulate G protein signaling by controlling localization and activity of the RGS7 complexes<\/span><\/a>
Journal of Cell Biology<\/span><\/em> (2012) 197:711-719. <\/p><\/h3><\/td><\/tr>

\"\"<\/td>

3. <\/strong>Cao, Y., Pahlberg, J., Sarria, I., Kamasaw,a N., Sampath, A.P., Martemyanov K.A<\/strong>.
Regulators of G protein signaling RGS7 and RGS11 determine the onset of the light response in ON bipolar neurons<\/span><\/a>
Proceedings of the National Academy of Sciences USA<\/span><\/em> (2012) 109:7905-7910. <\/p><\/h3><\/td><\/tr>

\"\"<\/td>

2.<\/strong> Xie, K., Ge, S., Collins, V.E., Haynes, C.L, Renner, K.J., Meisel, R.L., Lujan, R., Martemyanov, K.A.<\/strong>
G\u03b25-RGS complexes are gatekeepers of hyperactivity involved in control of multiple neurotransmitter systems<\/span><\/a>
Psychoparmacology<\/span><\/em> (2012) 219:823-834. <\/p><\/h3><\/td><\/tr>

\"\"<\/td>

1. <\/strong>Terzi D., Cao Y., Agrimaki I., Martemyanov K.A<\/strong>., Zachariou V.
R7BP modulates opiate analgesia and tolerance but not withdrawal<\/span><\/a>
Neuropsychopharmacology<\/span><\/em> (2012) 37:1005-1012. <\/p><\/h3><\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n

2011<\/h3>\n\n\n\n
\"\"<\/td>

5. <\/strong>Xie K. and Martemyanov K.A.<\/strong> 
Control of striatal signaling by g protein regulators<\/span><\/a>
Frontiers in Neuroanatomy<\/span><\/em> (2011) 5:49. <\/p><\/h3><\/td><\/tr>

\"\"<\/td>

4.<\/strong> Cao Y., Posokhova E., and Martemyanov K.A.<\/strong> 
TRPM1 forms complexes with nyctalopin in vivo and accumulates in postsynaptic compartment of ON-bipolar neurons in mGluR6-dependent manner<\/span><\/a>
The Journal of Neuroscience<\/span> <\/em>(2011) 31:11521-11526. <\/p><\/h3><\/td><\/tr>

\"\"<\/td>

3. <\/strong>Gopalakrishna K.N., Doddapuneni K., Boyd K.K., Masuho I, Martemyanov K.A.<\/strong>, and Artemyev N.O.
Interaction of transducin with uncoordinated 119 protein (UNC119): implications for the model of transducin trafficking in rod photoreceptors<\/span><\/a>
Journal of Biological Chemistry<\/span><\/em> (2011) 286:28954-28962.<\/p><\/h3><\/td><\/tr>

\"\"<\/td>

2. <\/strong>Masuho I., Wakasugi-Masuho H., Posokhova E.N., Patton J.R., and Martemyanov K.A.<\/strong>
Type 5 G protein beta subunit (Gbeta5) controls the interaction of regulator of G protein signaling 9 (RGS9) with membrane anchors<\/span><\/a>
Journal of Biological Chemistry<\/span><\/em> (2011) 286:21806-21813. <\/p><\/h3><\/td><\/tr>

\"\"<\/td>

1.<\/strong> Posokhova E., Song H., Belcastro M., Higgins L., Bigley L.R., Michaud N.A., Martemyanov K.A.<\/strong>, and Sokolov M.
Disruption of the chaperonin containing TCP-1 function in rods affects multiple protein networks and arrests outer segment morphogenesis<\/span><\/a>
Molecular & Cellular Proteomics<\/span><\/em> (2011) 10:M110.000570. <\/p><\/h3><\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n

2010<\/h3>\n\n\n\n
\"\"<\/td>

9. <\/strong>Porter M.Y., Xie K., Pozharski E., Koelle M.R., and Martemyanov K.A.<\/strong>
A conserved protein interaction interface on the type 5 G protein beta subunit controls proteolytic stability and activity of R7 family regulator of G protein signaling proteins<\/span><\/a>
Journal of Biological Chemistry<\/span><\/em> (2010) 285:41100-41112. <\/p><\/h3><\/td><\/tr>

\"\"<\/td>

8. <\/strong>Posokhova E., Wydeven N., Allen K.L., Wickman K., and Martemyanov K.A.<\/strong>
RGS6\/Gbeta5 complex accelerates IKACh gating kinetics in atrial myocytes and modulates parasympathetic regulation of heart rate<\/span><\/a>
Circulation Research<\/span><\/em> (2010) 107:1350-1354. <\/p><\/h3><\/td><\/tr>

\"\"<\/td>

7. <\/strong>Cao Y., Kolesnikov A.V., Masuho I., Kefalov V.J., and Martemyanov K.A<\/strong>.
Membrane anchoring subunits specify selective regulation of RGS9-Gbeta5 GAP complex in photoreceptor neurons<\/span><\/a>
The Journal of Neuroscience<\/span><\/em> (2010) 30:13784-13793. <\/p><\/h3><\/td><\/tr>

\"\"<\/td>

6.<\/strong> Xie K., Allen K.L., Kourrich S., Col\u00f3n-Saez J., Thomas, M.J., Wickman K., and Martemyanov K.A.<\/strong>
Gbeta5 recruits R7 RGS proteins to GIRK channels to regulate the timing of neuronal inhibitory signaling<\/span><\/a>
Nature Neuroscience<\/span><\/em> (2010) 13:661-663. <\/p><\/h3><\/td><\/tr>

\"\"<\/td>

5. <\/strong>Panicker L.M., Zhang J.H., Posokhova E., Gastinger M.J., Martemyanov K.A<\/strong>., and Simonds W.F.
Nuclear localization of the G protein beta5\/R7-regulator of G protein signaling protein complex is dependent on R7 binding protein<\/span><\/a>
Journal of Neurochemistry<\/span><\/em> (2010) 113:1101-1112. <\/p><\/h3><\/td><\/tr>

\"\"<\/td>

4.<\/strong> Posokhova E., Uversky V., and Martemyanov K.A.<\/strong>
Proteomic identification of Hsc70 as a mediator of RGS9-2 degradation by in vivo interactome analysis<\/span><\/a>
Journal of Proteome Research<\/span><\/em> (2010) 9:1510-1521. <\/p><\/h3><\/td><\/tr>

\"\"<\/td>

3. <\/strong>Roloff A.M., Anderson G.R., Martemyanov K.A<\/strong>., and Thayer S.A.
Homer 1a gates the induction mechanism for endocannabinoid-mediated synaptic plasticity<\/span><\/a>
The Journal of Neuroscience<\/em><\/span> (2010) 30:3072-3081 <\/p><\/h3><\/td><\/tr>

\"\"<\/td>

2.<\/strong> Anderson G.R., Cao Y., Davidson S., Truong H.V., Pravetoni M., Thomas M.J., Wickman K., Giesler G.J. Jr., and Martemyanov K.A.<\/strong>
R7BP complexes with RGS9-2 and RGS7 in the striatum differentially control motor learning and locomotor responses to cocaine<\/span><\/a>
Neuropsychopharmacology<\/span><\/em> (2010) 35:1040-1050. <\/p><\/h3><\/td><\/tr>

\"\"<\/td>

1. <\/strong>Masuho I., Celver J., Kovoor A., and Martemyanov K.A<\/strong>.
Membrane anchor R9AP potentiates GTPase-accelerating protein activity of RGS11\/Gbeta5 complex and accelerates inactivation of the mGluR6-Go signaling<\/span><\/a>
Journal of Biological Chemistry<\/span><\/em> (2010) 285:4781-4787. <\/p><\/h3><\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n

2009<\/h3>\n\n\n\n
\"\"<\/td>

4. <\/strong>Anderson , G.R., Posokhova E., and Martemyanov K.A.<\/strong>
The R7 RGS protein family: multi-subunit regulators of neuronal G protein signaling<\/span><\/a>
Cell Biochemistry and Biophysics<\/span><\/em> (2009) 54:33-46. <\/p><\/h3><\/td><\/tr>

\"\"<\/td>

3.<\/strong> Martemyanov K.A.<\/strong> and Arshavsky V.Y.
Biology and functions of the RGS9 isoforms<\/span><\/a>
Progress in Molecular Biology and Translational Science<\/span><\/em> (2009) 86:205-207.<\/p><\/h3><\/td><\/tr>

\"\"<\/td>

2. <\/strong>Cao Y., Masuho I., Okawa H., Xie K, Asami J., Kammermeier P., Furukawa T., Inoue Y., Sampath A.P., and Martemyanov K.A.<\/strong>
Retina-specific GTPase accelerator RGS11\/Gbeta5S\/R9AP is a constitutive heterotrimer selectively targeted to mGluR6 in ON-bipolar neurons<\/span><\/a>
The Journal of Neuroscience<\/span><\/em> (2009) 29:9301-9313.<\/p><\/h3><\/td><\/tr>

\"\"<\/td>

1. <\/strong>Anderson G.R., Lujan R., and Martemyanov K.A.<\/strong>
Changes in striatal signaling induce remodeling of RGS complexes containing Gbeta5 and R7BP subunits<\/span><\/a>
Molecular and Cellular Biology<\/span><\/em>  (2009) 29:3033-3044. <\/p><\/h3><\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n

2008<\/h3>\n\n\n\n
\"\"<\/td>

4.<\/strong> Martemyanov K.A.<\/strong>, Krispel C.M., Lishko P.V., Burns M.E., and Arshavsky V.Y.
Functional comparison of RGS9 splice isoforms in a living cell<\/span><\/a>
Proceedings of the National Academy of Sciences USA<\/span><\/em> (2008) 105:20988-20993. <\/p><\/h3><\/td><\/tr>

\"\"<\/td>

3. <\/strong>Hooks S., Martemyanov K.<\/strong>, and Zachariou V.
A role of RGS proteins in drug addiction<\/span><\/a>
Biochemical Pharmacology<\/span><\/em> (2008) 75:76-84. <\/p><\/h3><\/td><\/tr>

\"\"<\/td>

2. <\/strong>Kim H.J., Martemyanov K.A.<\/strong>, and Thayer S.A.
Human immunodeficiency virus protein Tat induces synapse loss via a reversible process that is distinct from cell death<\/span><\/a>
The Journal of Neuroscience<\/span><\/em> (2008) 28:12604-12613. <\/p><\/h3><\/td><\/tr>

\"\"<\/td>

1. <\/strong>Cao Y., Song H., Okawa H., Sampath A.P., Sokolov M., and Martemyanov K.A.<\/strong>
Targeting of RGS7\/G5 to the dendritic tips of ON-bipolar cells is independent of its association with membrane anchor R7BP<\/span><\/a>
The Journal of Neuroscience<\/span><\/em> (2008) 28:10443:10449. <\/p><\/h3><\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n

2007<\/h3>\n\n\n\n
\"\"<\/td>

3. <\/strong>Anderson G.R., Lujan R., Semenov A., Pravetoni M., Posokhova E.N., Song J.H., Uversky V., Chen C-K., Wickman K., and Martemyanov K.A.<\/strong>
Expression and localization of RGS9-2\/Gbeta5\/R7BP complex in vivo is set by dynamic control of its constitutive degradation by cellular cysteine proteases<\/span><\/a>
The Journal of Neuroscience<\/span><\/em> (2007) 27:14117-14127.<\/p><\/h3><\/td><\/tr>

\"\"<\/td>

2. <\/strong>Song J.H., Song H., Wensel T.G., Sokolov M., and Martemyanov K.A<\/strong>.
Localization and differential interaction of R7 RGS proteins with their membrane anchors R7BP and R9AP in neurons of vertebrate retina<\/span><\/a>
Molecular and Cellular Neuroscience<\/span><\/em> (2007) 35:311-319. <\/p><\/h3><\/td><\/tr>

\"\"<\/td>

1. <\/strong>Anderson G.R., Semenov A., Song J.H., Martemyanov K.A.<\/strong>
The membrane anchor R7BP controls the proteolytic stability of the striatal specific RGS protein, RGS9-2<\/span><\/a>
Journal of Biological Chemistry<\/em><\/span> <\/em>(2007) 282:4772-4781. <\/p><\/h3><\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n

2006<\/h3>\n\n\n\n
\"\"<\/td>

1.<\/strong> Song J.H., Waataja J.J., Martemyanov K.A<\/strong>.
Subcellular targeting of RGS9-2 is controlled by multiple molecular determinants on its membrane anchor, R7BP<\/span><\/a>
Journal of Biological Chemistry<\/span><\/em> (2006) 281:15361-15369.<\/p><\/h3><\/td><\/tr><\/tbody><\/table><\/figure>\n","protected":false},"excerpt":{"rendered":"

The following articles were published by Kirill Martemyanov, his lab members and his collaborators. To move from the citations below to full articles in the National Library of Medicine’s PubMed archive, click on each paper’s title in blue. You can also search annual publications by clicking directly on the years below. Martemyanov Publications by Year: 2026 | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 2026 1. Laboute T, Zucca S, Sial OK, Sharma M, Brunori G, Singh S, Nageswar KV, Peng H, Rader C, Becker JA, Le Merrer J, Singh AK, Martemyanov KA. Targeting mGlyR with nanobodies for depression. Nature Communications 2026 Jan 26;17(1):831. doi: 10.1038\/s41467-026-68339-x. 2025 10. Ludlam WG, Dom\u00ednguez-Carral J, Schteinschnaider A, Martemyanov KA, Ortigoza-Escobar JD. Novel\u00a0GNAO1\u00a0variant in \u03b1-helical domain reveals alternative mechanism of disease. Genes and Diseases 2025 Nov 21;13(2):101714. doi: 10.1016\/j.gendis.2025.101714. 9. Shishikura K, Li J, Chen Y, McKnight NR, Keeley TP, Bustin KA, Barr EW, Chilkamari SR, Ayub M, Kim SW, Lin Z, Hu RM, Hicks K, Wang X, O’Rourke DM, Martin Bollinger J Jr, Binder ZA, Parsons WH, Martemyanov KA, Liu A, Matthews ML. Hydralazine inhibits cysteamine dioxygenase to treat preeclampsia and senesce glioblastoma. Science Advances 2025 Oct 17;11(42):eadx7687. doi: 10.1126\/sciadv.adx7687 8. Ren Q, Wang J, Idikuda V, Zhang S, Shin J, Ludlam WG, Real Hernandez LM, Zdancewicz S, Kreutzberger AJB, Chang H, Kiessling V, Tamm LK, Jomaa A, Levental I, Martemyanov KA, Chanda B, Bao H. DeFrND: detergent-free reconstitution into native nanodiscs with designer membrane scaffold peptides. Nature Communications 2025 Aug 26;16(1):7973. doi: 10.1038\/s41467-025-63275-8. 7. Li X, Winters ND, Pandey S, Lankford C, Stoveken H, Smith E, Chang CT, Zucca S, Scampavia L, Spicer T, Martemyanov KA.Homeostatic scaling of dynorphin signaling by a non-canonical opioid receptorNature Communications 2025 Jul 23;16(1):6786. doi: 10.1038\/s41467-025-62133-x. 6. Aguado C, Fajardo-Serrano A, Alfaro-Ruiz R, Mart\u00ednez-Poyato ML, Moreno-Mart\u00ednez AE, Garc\u00eda-Madrona S, Rold\u00e1n-Sastre A, Alonso-G\u00f3mez P, Fern\u00e1ndez M, Puertas-Avenda\u00f1o R, Shigemoto R, Martemyanov KA, Lujan R Developmental regulation of GABAB receptors and downstream molecules in the mouse brainHistology and Histopathology 2025 Jul 18:18970. doi: 10.14670\/HH-18-970. 5. Wang T, Dom\u00ednguez-Carral J, Ludlam WG, Segarra MJ, Marti MF, Bruining H, Martemyanov KA, Linkenkaer-Hansen K, Ortigoza-Escobar JD Neuronal oscillatory imbalances in GNAO1-related disorders associated with disease severityEpilespia 2025 Jun 27. doi: 10.1111\/epi.18513. 4. Dore R, Chang C, Decl\u00e8ve A, Brunori G, Ludlam WG, Huang A, Movahedinia M, Damseh N, Anwar I, Mehrjardi MYV, Ny A, Khorrami M, Kheirollahi M, Frederiksen H, Eghbal F, Mirjalili MR, Dehghani M, Karimiani EG, Oreshkov S, Alves C, Striano P, Suri M, Martinez-Agosto J, Ansar M, Zahid M, Akram S, Ansar M, Nelson S; Undiagnosed Diseases Network; Antonarakis SE, Houlden H, Copmans D, Martemyanov KA, Maroofian RELFN1 deficiency: The mechanistic basis and phenotypic spectrum of a neurodevelopmental disorder with epilepsyGenetics in Medecine 2025 Jun 23;27(9):101506. 3. Zhao C, Cao Y, Ibrahim N, Wang Y, Martemyanov KA.Efficient in vivo labeling of endogenous proteins with SMART delineates retina cellular and synaptic organizationNature Communications 2025  Apr 22;16(1):3768. 2. Zucca S, Brunori G, Dunn H, Lankford C, Sutton L, Flores BA, Maza N, Sial O, Crynen G, Luj\u00e1n R, Martemyanov KA.Trans-synaptic modulation of cholinergic circuits tunes opioid reinforcementProceedings of the National Academy of Sciences USA 2025 Mar 25;122(12):e2409325122. 1. Dunn H, Dhaliwal SK, Chang CT, Martemyanov KA.Distinct autoregulatory roles of ELFN1 intracellular and extracellular domains on membrane trafficking, synaptic localization, and dimerizationJournal of Biological Chemistry (2025) 301(1):108073. 2024 5. Luo H, Anderson A, Masuho I, Fernandez de Velasco EM, Birnbaumer L, Martemyanov KA, Wickman K.Receptor-dependent influence of R7 RGS proteins on neuronal GIRK channel signaling dynamicsProgress in Neurobiology (2024) 102686. 4. Yun Y, Jeong H, Laboute T, Martemyanov KA, Lee HH.Cryo-EM structure of human class C orphan GPCR GPR179 involved in visual processingNature Communications (2024) 15:8299. 3. Knight K, Krumm B, Kapolka N, Ludlam WG, Cui M, Manu S, Prytkova I, Obarow EG, Lefevre TJ, Wei W, Ma N, Huang XP, Fay JF, Vaidehi N, Smrcka AV, Slesinger PA, Logothetis DE, Martemyanov KA. Roth, BL, Dohlman HG. A neurodevelopmental disorder mutation locks G proteins in the transitory pre-activated stateNature Communication (2024) 15(1):6643. 2. Ludlam WG, Soliani L, Dom\u00ednguez-Carral J, Cordelli DM, Marchiani V, Gorr\u00eda-Redondo N, Aguilera-Albesa S, Martemyanov KA, Ortigoza-Escobar JDDiverse faces of GNAO1: mild forms in epilepsy and autismJournal of Neurology (2024) 271(7), 3777\u20133781. 1. Nelic D, Chetverikov N, Hochmalov\u00e1 M, Diaz C, Dole\u017eal V, Boulos J, Jakub\u00edk J, Martemyanov KA, Janou\u0161kov\u00e1-Rand\u00e1kov\u00e1 A.Agonist-selective activation of individual G-proteins by muscarinic receptorsScientific Reports (2024) 14(1):9652. 2023 5. Dom\u00ednguez-Carral J, Ludlam WG, Junyent Segarra M, Fornaguera Marti M, Balsells S, Muchart J, \u010cokoli\u0107 Petrovi\u0107 D, Espinoza I, Ortigoza-Escobar JD, Martemyanov KA, GNAO1-Study Group.Severity of GNAO1-Related Disorder Correlates with Changes in G-Protein FunctionAnnals of Neurology (2023) 26758. 4. Masuho I, Kise R, Gainza P, Von Moo E, Li X, Tany R, Wakasugi-Masuho H, Correia BE, Martemyanov KA. Rules and mechanisms governing G protein coupling selectivity of GPCRsCell Rep (2023) 113173. 3. Patil DN, Pantalone S, Cao Y, Laboute T, Novick SJ, Singh S, Savino S, Faravelli S, Magnani F, Griffin PR, Singh AK, Forneris F, Martemyanov KA. Structure of the photoreceptor synaptic assembly of the extracellular matrix protein pikachurin with the orphan receptor GPR179Sci Signal (2023) 16:eadd9539. 2. Park J-C, Luebbers A, Dao M, Semeano A, Nguyen AM, Papakonstantinou MP, Broselid S, Yano H, Martemyanov KA, Garcia-Marcos M.Fine-tuning GPCR-mediated neuromodulation by biasing signaling through different G protein subunitsMoll Cell (2023) 83:2540-2558. 1. Laboute T, Zucca S, Holcomb M, Patil DN, Garza C, Wheatley BA, Roy RN, Forli S, Martemyanov KA.Orphan receptor GPR158 serves as a metabotropic glycine receptor: mGlyRScience (2023) 379:1352-1358. 2022 9. Ives AN, Dunn HA, Afsari HS, Seckler HDS, Foroutan MJ, Chavez E, Melani RD, Fellers RT, LeDuc RD, Thomas PM, Martemyanov KA, Kelleher NL, Vafabakhsh R.Middle-Down Mass Spectrometry Reveals Activity-Modifying Phosphorylation Barcode in a Class C G Protein-Coupled ReceptorJ Am Chem Soc. (2022) 144(50):23104-23114. 8. Campla C, Bocchero U, Strickland R, Nellissery J, Advani J, Ignatova I, Srivastava D, Aponte A, Wang Y, Gumerson J, Martemyanov KA, Artemyev N, Pahlberg J, Swaroop A.Frmpd1 facilitates trafficking of G-protein transducin and modulates synaptic function in rod photoreceptors of mammalian retinaeNeuro. (2022) 30:ENEURO.0348-22.2022. 7. Maza N, Wang D, Kowalski C, Stoveken H, Dao M, Sial O, Giles A, Grill, Martemyanov KA.Ptchd1 mediates opioid tolerance via cholesterol-dependent effects on \u03bc-opioid receptor traffickingNat Neurosci. (2022) 25:1179-1190. 6. Cao Y, Fajardo D, Guerrero-Given D, Samuel MA, Ohtsuka T, Boye SE, Kamasawa N, Martemyanov KA.Post-developmental plasticity of the primary rod pathway allows restoration of visually guided behaviorsCurr Biol. (2022) S0960-9822 01460-9. 5. Beier C, Bocchero U, Levy L, Martemyanov KA, Hattar S, Pahlberg J.Divergent outer retinal circuits drive image and non-image visual behaviorsCell Rep (2022) 28;39:111003. 4. Marwari S, Kowalski C, Martemyanov KA.Exploring pharmacological inhibition of G q\/11 as an analgesic strategyBr J Pharmacol (2022) 10.1111\/bph.15935. 3. Hopkins B, Masuho I, Ren D, Iyamu I, Lv W, Malik N, Martemyanov KA, Schiltz G, Miller R.Effects of Small Molecule Ligands on ACKR3 ReceptorsMol Pharmacol (2022) 10.1124\/molpharm.121.000295. 2. Muntean BS, Marwari S, Li X, Sloan DC, Young BD, Wohlschlegel JA, Martemyanov KA.Members of the KCTD family are major regulators of cAMP signaling.Proceedings of the National Academy of Sciences USA (2022) 119:e2119237119. 1. Patil DN, Singh S, Laboute T, Strutzenberg TS, Qiu X, Wu D, Novick SJ, Robinson CV, Griffin PR, Hunt JF, Izard T, Singh AK, Martemyanov KA. Cryo-EM structure of human GPR158 receptor coupled to the RGS7-G\u03b25 signaling complexScience (2021) 375:86-91. 2021 11. Wang Y, Cao Y, Hays CL, Laboute T, Ray TA, Guerrero-Given D, Ahuja AS, Patil D, Rivero O, Kamasawa N, Kay JN, Thoreson WB, Martemyanov KA. Adhesion GPCR Latrophilin 3 regulates synaptic function of cone photoreceptors in a trans-synaptic mannerProceedings of the National Academy of Sciences USA (2021) 118:e2106694118. 10. Wang D., Dao M., Muntean B.S., Giles A.C., Martemyanov K.A., Grill B. Genetic modeling of GNAO1 disorder delineates mechanisms of G\u03b1o dysfunctionHuman Molecular Genetics (2021) in press. 9. Shao, Z., Masuho, I., Tumber, A., Maynes, J.T., Tavares, E., Ali, A., Hewson, S., Schulze, A., Kannu, P., Martemyanov, K.A, Vincent A.Extended phenotyping and functional validation facilitate diagnosis of a complex patient harboring genetic variants in MCCC1 and GNB5 causing overlapping phenotypesGenes (Basel) (2021) 12:1352. 8. Moo EV., Harps\u00f8e K., Hauser A.S., Masuho I., Br\u00e4uner-Osborne H., Gloriam D.E., Martemyanov K.A. Ligand-directed bias of G protein signaling at the dopamine D2 receptorCell Chemical Biology (2021) in press. 7. Stoveken H.M., Fernandez-Vega V., Muntean B.S., Patil D.N., Shumate J., Bannister T.D., Scampavia L., Spicer T.P., Martemyanov K.A. Identification of potential modulators of the RGS7\/G\u03b25\/R7BP complexSLAS Discovery (2021) 26:1177-1188. 6. Martemyanov K.A.Mechanisms of G\u03b2\u03b3 release upon GPCR activationTrends in Biochemical Sciences (2021) 46:703-704. 5. Masuho I., Skamangas N.K., Muntean B.S., Martemyanov K.A.Diversity of the G\u03b2\u03b3 complexes defines spatial and temporal bias of GPCR signaling Cell Systems (2021) 12:324-337.e5. 4. Muntean B.S., Masuho I., Dao M., Sutton L.P., Zucca S., Iwamoto H., Patil D.N., Wang D., Birnbaumer L., Blakely R.D., Grill B., Martemyanov K.A.G\u03b1o is a major determinant of cAMP signaling in the pathophysiology of movement disordersCell Reports (2021) 34:108718. 3. Dao M., Stoveken H.M., Cao Y., Martemyanov K.A.The role of orphan receptor GPR139 in neuropsychiatric behaviorNeuropsychopharmacology (2021) in press. 2. Melis C., Beauvais G., Muntean B.S., Cirnaru M.D., Otrimski G., Creus-Muncunill J., Martemyanov K.A., Gonzalez-Alegre P., Ehrlich M.E.Striatal dopamine induced ERK phosphorylation is altered in mouse models of monogenic dystoniaMovement Disorders (2021) 36:1147-1157. 1. Sutton L.P., Khalatyan N., Savas J.N., Martemyanov K.A.Striatal RGS7 regulates depression-related behaviors and stress-induced reinstatement of cocaine conditioned place preferenceeNeuro. (2021) 8:ENEURO.0365-20.2020. 2020 8. Masuho I., Balaji S., Muntean B.S., Skamangas N.K., Chavali S., Tesmer J.J.G., Babu M.M., Martemyanov K.A. A global map of G protein signaling regulation by RGS proteinsCell (2020)  183:503-521.e19.  7. Bartoszek A., Moo E.V., Binienda A., Fabisiak A., Krajewska J.B., Mosi\u0144ska P., Niewinna K., Tarasiuk A., Martemyanov K.A., Salaga M., Fichna J. Free fatty acid receptors as new potential therapeutic target in inflammatory bowel diseases  Pharmaceutical Research (2020) 152:104604.  6. Anderson A., Masuho I., Marron Fernandez de Velasco E., Nakano A., Birnbaumer L., Martemyanov K.A., Wickman K. GPCR-dependent biasing of GIRK channel signaling dynamics by RGS6 in mouse sinoatrial nodal cells Proceedings of the National Academy of Sciences USA (2020) 117:14522-14531.   5. Stoveken H.M, Zucca S., Masuho I., Grill B., Martemyanov K.A. The orphan receptor GPR139 signals via Gq\/11 to oppose opioid effects  Journal of Biological Chemistry (2020) 295:10822-10830. 4. Schultz-Rogers L., Masuho I., Pinto e Vairo F., Schmitz C.T., Schwab T.L., Clark K.J., Gunderson L., Pichurin P.N., Wierenga K., Martemyanov K.A., Klee E.W.Haploinsufficiency as a disease mechanism in GNB1-associated neurodevelopmental disorderMolecular Genetics and Genomic Medicine (2020) 8:e1477.   3. Cao Y., Wang Y., Dunn H.A., Orlandi C., Shultz N., Kamasawa N., Fitzpatrick D., Li W., Zeitz C., Hauswirth W., Martemyanov K.A.Interplay between cell adhesion molecules governs synaptic wiring of cone photoreceptors   Proceedings of the National Academy of Sciences USA (2020) 117:23914-23924. 2. Xu L., Bolch S.N., Santiago C.P., Dyka F.M., Akil O., Lobanova E., Wang Y., Martemyanov K.A., Hauswirth W.W., Smith W.C., Handa J.T., Blackshaw S., Ash J.D., Dinculescu A.Clarin-1 expression in adult mouse and human retina highlights a role of M\u00fcller Glia in Usher Syndrome The Journal of Pathology (2020) 250:195-204. 1. Masuho, I., Skamangas, N.K., Martemyanov, K.A.Live cell optical assay for precise characterization of receptors coupling to G\u03b112Basic & Clinical Pharmacology & Toxicology (2020) 126 Suppl 6:88-95. 2019 12. Doyle T., Muntean B., Ejendal K., Hayes M., Soto-Velasquez M., Martemyanov K.A., Dessauer C., Hu C.D., Watts V.Identification of novel adenylyl cyclase 5 (AC5) signaling networks in D1 and D2 medium spiny neurons using bimolecular fluorescence complementation screeningCell (2019) 8:1468. 11. Green M.V., Pengo T., Raybuck J.D., Naqvi T., McMullan H.M, Hawkinson J.E., Fernandez de Velasco E.M., Muntean B.S., Martemyanov K.A., Satterfield R., Young S.M., Thayer S.A.Automated live-cell imaging of synapses in rat and human neuronal culturesFrontiers in Cellular Neuroscience (2019) 13:467. 10. Sutton L.P., Muntean B.S., Ostrovskaya O., Zucca S., Dao M., Orlandi C., Song C., Xie K., Martemyanov K.A.NF1-cAMP signaling dissociates cell type specific contributions of striatal medium spiny neurons to reward valuation and motor controlPLOS Biology (2019) 17:e3000477.  9. Cirnaru, M.D., Melis, C., Fanutza, T., Naphade, S., Tshilenge, K.N., Muntean, B.S., Martemyanov, K.A., Plotkin, J.L., Ellerby,…<\/p>\n","protected":false},"author":4,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-4095","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/martemyanovlab.com\/index.php\/wp-json\/wp\/v2\/pages\/4095","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/martemyanovlab.com\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/martemyanovlab.com\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/martemyanovlab.com\/index.php\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/martemyanovlab.com\/index.php\/wp-json\/wp\/v2\/comments?post=4095"}],"version-history":[{"count":44,"href":"https:\/\/martemyanovlab.com\/index.php\/wp-json\/wp\/v2\/pages\/4095\/revisions"}],"predecessor-version":[{"id":4328,"href":"https:\/\/martemyanovlab.com\/index.php\/wp-json\/wp\/v2\/pages\/4095\/revisions\/4328"}],"wp:attachment":[{"href":"https:\/\/martemyanovlab.com\/index.php\/wp-json\/wp\/v2\/media?parent=4095"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}