Welcome to the Martemyanov Laboratory

Department of Neuroscience | Scripps Biomedical Research | Jupiter, Florida

Our Research:

The main emphasis of research in the laboratory is the fundamental principles that regulate signaling via G protein coupled receptors (GPCR). GPCRs mediate a vast variety of critical biological processes ranging from proliferation and motility to cellular reception and excitability. GPCR signaling pathways are of particular importance for the nervous system function where they control many fundamental processes including excitability, differentiation, sensory perception and synaptic transmission. Importantly, but not surprisingly, even subtle imbalances in GPCR signaling often lead to the most profound nervous system disorders ranging from blindness and cognitive problems to grave neurological diseases. 

Representative Papers:

Maza N, Wang D, Kowalski C, Stoveken HM, Dao M, Sial OK, Giles AC, Grill B, Martemyanov KA.
Ptchd1 mediates opioid tolerance via cholesterol-dependent effects on μ-opioid receptor trafficking
Nat Neurosci (2022) 25:1179-1190.

Patil DN, Singh S, Laboute T, Strutzenberg TS, Qiu X, Wu D, Novick SJ, Robinson CV, Griffin PR, Hunt JF, Izard T, Singh AK, Martemyanov KA.
Cryo-EM structure of human GPR158 receptor coupled to the RGS7-Gβ5 signaling complex
Science (2022) 375, 86-91.

Masuho I, Balaji S, Muntean BS, Skamangas NK, Chavali S, Tesmer JJG, Babu MM, Martemyanov KA.
A global map of G protein signaling regulation by RGS proteins
(2020) 183:503-521. 

Wang D, Stoveken HM, Zucca S, Dao M, Orlandi C, Song C, Masuho I, Johnston C, Opperman KJ, Giles AC, Gill MS, Lundquist EA, Grill B, Martemyanov KA.
Genetic behavioral screen identifies an orphan anti-opioid system
Science (2019) 20, 1267-1273.  

Wang Y, Fehlhaber KE, Sarria I, Cao Y, Ingram NT, Guerrero-Given D, Throesch B, Baldwin K, Kamasawa N, Ohtsuka T, Sampath AP, Martemyanov KA.
The auxiliary calcium channel subunit α2δ4 is required for axonal elaboration, synaptic transmission, and wiring of rod photoreceptors
(2017) 93:1359-1374.e6

Learn More About Our Work: