The following articles were published by Kirill Martemyanov, his lab members and his collaborators. To move from the citations below to full articles in the National Library of Medicine’s PubMed archive, click on each paper’s title in blue. You can also search annual publications by clicking directly on the years below.

Martemyanov Publications by Year:

2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006


5. Domínguez-Carral J, Ludlam WG, Junyent Segarra M, Fornaguera Marti M, Balsells S, Muchart J, Čokolić Petrović D, Espinoza I, Ortigoza-Escobar JD, Martemyanov KA, GNAO1-Study Group.
Severity of GNAO1-Related Disorder Correlates with Changes in G-Protein Function
Annals of Neurology (2023) 26758.

4. Masuho I, Kise R, Gainza P, Von Moo E, Li X, Tany R, Wakasugi-Masuho H, Correia BE, Martemyanov KA.
Rules and mechanisms governing G protein coupling selectivity of GPCRs
Cell Rep
(2023) 113173.

Science Signaling

3. Patil DN, Pantalone S, Cao Y, Laboute T, Novick SJ, Singh S, Savino S, Faravelli S, Magnani F, Griffin PR, Singh AK, Forneris F, Martemyanov KA.
Structure of the photoreceptor synaptic assembly of the extracellular matrix protein pikachurin with the orphan receptor GPR179
Sci Signal
(2023) 16:eadd9539.

Molecular Cell July 2023

2. Park J-C, Luebbers A, Dao M, Semeano A, Nguyen AM, Papakonstantinou MP, Broselid S, Yano H, Martemyanov KA, Garcia-Marcos M.
Fine-tuning GPCR-mediated neuromodulation by biasing signaling through different G protein subunits
Moll Cell
(2023) 83:2540-2558.

1. Laboute T, Zucca S, Holcomb M, Patil DN, Garza C, Wheatley BA, Roy RN, Forli S, Martemyanov KA.
Orphan receptor GPR158 serves as a metabotropic glycine receptor: mGlyR
(2023) 379:1352-1358.


9. Ives AN, Dunn HA, Afsari HS, Seckler HDS, Foroutan MJ, Chavez E, Melani RD, Fellers RT, LeDuc RD, Thomas PM, Martemyanov KA, Kelleher NL, Vafabakhsh R.
Middle-Down Mass Spectrometry Reveals Activity-Modifying Phosphorylation Barcode in a Class C G Protein-Coupled Receptor
J Am Chem Soc.
(2022) 144(50):23104-23114.

8. Campla C, Bocchero U, Strickland R, Nellissery J, Advani J, Ignatova I, Srivastava D, Aponte A, Wang Y, Gumerson J, Martemyanov KA, Artemyev N, Pahlberg J, Swaroop A.
Frmpd1 facilitates trafficking of G-protein transducin and modulates synaptic function in rod photoreceptors of mammalian retina
(2022) 30:ENEURO.0348-22.2022.

7. Maza N, Wang D, Kowalski C, Stoveken H, Dao M, Sial O, Giles A, Grill, Martemyanov KA.
Ptchd1 mediates opioid tolerance via cholesterol-dependent effects on μ-opioid receptor trafficking
Nat Neurosci.
(2022) 25:1179-1190.

6. Cao Y, Fajardo D, Guerrero-Given D, Samuel MA, Ohtsuka T, Boye SE, Kamasawa N, Martemyanov KA.
Post-developmental plasticity of the primary rod pathway allows restoration of visually guided behaviors
Curr Biol.
(2022) S0960-9822 01460-9.

5. Beier C, Bocchero U, Levy L, Martemyanov KA, Hattar S, Pahlberg J.
Divergent outer retinal circuits drive image and non-image visual behaviors
Cell Rep
(2022) 28;39:111003.

4. Marwari S, Kowalski C, Martemyanov KA.
Exploring pharmacological inhibition of G q/11 as an analgesic strategy
Br J Pharmacol
(2022) 10.1111/bph.15935.

3. Hopkins B, Masuho I, Ren D, Iyamu I, Lv W, Malik N, Martemyanov KA, Schiltz G, Miller R.
Effects of Small Molecule Ligands on ACKR3 Receptors
Mol Pharmacol
(2022) 10.1124/molpharm.121.000295.

2. Muntean BS, Marwari S, Li X, Sloan DC, Young BD, Wohlschlegel JA, Martemyanov KA.
Members of the KCTD family are major regulators of cAMP signaling.
Proceedings of the National Academy of Sciences USA
(2022) 119:e2119237119.

1. Patil DN, Singh S, Laboute T, Strutzenberg TS, Qiu X, Wu D, Novick SJ, Robinson CV, Griffin PR, Hunt JF, Izard T, Singh AK, Martemyanov KA
Cryo-EM structure of human GPR158 receptor coupled to the RGS7-Gβ5 signaling complex
Science (2021) 375:86-91.


11. Wang Y, Cao Y, Hays CL, Laboute T, Ray TA, Guerrero-Given D, Ahuja AS, Patil D, Rivero O, Kamasawa N, Kay JN, Thoreson WB, Martemyanov KA
Adhesion GPCR Latrophilin 3 regulates synaptic function of cone photoreceptors in a trans-synaptic manner
Proceedings of the National Academy of Sciences USA (2021) 118:e2106694118.

10. Wang D., Dao M., Muntean B.S., Giles A.C., Martemyanov K.A., Grill B.
Genetic modeling of GNAO1 disorder delineates mechanisms of Gαo dysfunction
Human Molecular Genetics (2021) in press.

9. Shao, Z., Masuho, I., Tumber, A., Maynes, J.T., Tavares, E., Ali, A., Hewson, S., Schulze, A., Kannu, P., Martemyanov, K.A, Vincent A.
Extended phenotyping and functional validation facilitate diagnosis of a complex patient harboring genetic variants in MCCC1 and GNB5 causing overlapping phenotypes
Genes (Basel) (2021) 12:1352.

8. Moo EV., Harpsøe K., Hauser A.S., Masuho I., Bräuner-Osborne H., Gloriam D.E., Martemyanov K.A.
Ligand-directed bias of G protein signaling at the dopamine D2 receptor
Cell Chemical Biology (2021) in press.

7. Stoveken H.M., Fernandez-Vega V., Muntean B.S., Patil D.N., Shumate J., Bannister T.D., Scampavia L., Spicer T.P., Martemyanov K.A.
Identification of potential modulators of the RGS7/Gβ5/R7BP complex
SLAS Discovery (2021) 26:1177-1188.

6. Martemyanov K.A.
Mechanisms of Gβγ release upon GPCR activation
Trends in Biochemical Sciences (2021) 46:703-704.

5. Masuho I., Skamangas N.K., Muntean B.S., Martemyanov K.A.
Diversity of the Gβγ complexes defines spatial and temporal bias of GPCR signaling

Cell Systems (2021) 12:324-337.e5.

4. Muntean B.S., Masuho I., Dao M., Sutton L.P., Zucca S., Iwamoto H., Patil D.N., Wang D., Birnbaumer L., Blakely R.D., Grill B., Martemyanov K.A.
Gαo is a major determinant of cAMP signaling in the pathophysiology of movement disorders
Cell Reports (2021) 34:108718.

3. Dao M., Stoveken H.M., Cao Y., Martemyanov K.A.
The role of orphan receptor GPR139 in neuropsychiatric behavior
Neuropsychopharmacology (2021) in press.

2. Melis C., Beauvais G., Muntean B.S., Cirnaru M.D., Otrimski G., Creus-Muncunill J., Martemyanov K.A., Gonzalez-Alegre P., Ehrlich M.E.
Striatal dopamine induced ERK phosphorylation is altered in mouse models of monogenic dystonia
Movement Disorders (2021) 36:1147-1157.

1. Sutton L.P., Khalatyan N., Savas J.N., Martemyanov K.A.
Striatal RGS7 regulates depression-related behaviors and stress-induced reinstatement of cocaine conditioned place preference
eNeuro. (2021) 8:ENEURO.0365-20.2020.


8. Masuho I., Balaji S., Muntean B.S., Skamangas N.K., Chavali S., Tesmer J.J.G., Babu M.M., Martemyanov K.A. 
A global map of G protein signaling regulation by RGS proteins
Cell (2020)  183:503-521.e19. 

7. Bartoszek A., Moo E.V., Binienda A., Fabisiak A., Krajewska J.B., Mosińska P., Niewinna K., Tarasiuk A., Martemyanov K.A., Salaga M., Fichna J.
Free fatty acid receptors as new potential therapeutic target in inflammatory bowel diseases  
Pharmaceutical Research (2020) 152:104604. 

6. Anderson A., Masuho I., Marron Fernandez de Velasco E., Nakano A., Birnbaumer L., Martemyanov K.A., Wickman K.
GPCR-dependent biasing of GIRK channel signaling dynamics by RGS6 in mouse sinoatrial nodal cells 
Proceedings of the National Academy of Sciences USA (2020) 117:14522-14531.  

5. Stoveken H.M, Zucca S., Masuho I., Grill B., Martemyanov K.A. 
The orphan receptor GPR139 signals via Gq/11 to oppose opioid effects  
Journal of Biological Chemistry (2020) 295:10822-10830.

4. Schultz-Rogers L., Masuho I., Pinto e Vairo F., Schmitz C.T., Schwab T.L., Clark K.J., Gunderson L., Pichurin P.N., Wierenga K., Martemyanov K.A., Klee E.W.
Haploinsufficiency as a disease mechanism in GNB1-associated neurodevelopmental disorder
Molecular Genetics and Genomic Medicine (2020) 8:e1477.  

3. Cao Y., Wang Y., Dunn H.A., Orlandi C., Shultz N., Kamasawa N., Fitzpatrick D., Li W., Zeitz C., Hauswirth W., Martemyanov K.A.
Interplay between cell adhesion molecules governs synaptic wiring of cone photoreceptors   
Proceedings of the National Academy of Sciences USA (2020) 117:23914-23924.

2. Xu L., Bolch S.N., Santiago C.P., Dyka F.M., Akil O., Lobanova E., Wang Y., Martemyanov K.A., Hauswirth W.W., Smith W.C., Handa J.T., Blackshaw S., Ash J.D., Dinculescu A.
Clarin-1 expression in adult mouse and human retina highlights a role of Müller Glia in Usher Syndrome
The Journal of Pathology (2020) 250:195-204.

1. Masuho, I., Skamangas, N.K., Martemyanov, K.A.
Live cell optical assay for precise characterization of receptors coupling to Gα12
Basic & Clinical Pharmacology & Toxicology (2020) 126 Suppl 6:88-95.


12. Doyle T., Muntean B., Ejendal K., Hayes M., Soto-Velasquez M., Martemyanov K.A., Dessauer C., Hu C.D., Watts V.
Identification of novel adenylyl cyclase 5 (AC5) signaling networks in D1 and D2 medium spiny neurons using bimolecular fluorescence complementation screening
Cell (2019) 8:1468.

11. Green M.V., Pengo T., Raybuck J.D., Naqvi T., McMullan H.M, Hawkinson J.E., Fernandez de Velasco E.M., Muntean B.S., Martemyanov K.A., Satterfield R., Young S.M., Thayer S.A.
Automated live-cell imaging of synapses in rat and human neuronal cultures
Frontiers in Cellular Neuroscience (2019) 13:467.

10. Sutton L.P., Muntean B.S., Ostrovskaya O., Zucca S., Dao M., Orlandi C., Song C., Xie K., Martemyanov K.A.
NF1-cAMP signaling dissociates cell type specific contributions of striatal medium spiny neurons to reward valuation and motor control
PLOS Biology (2019) 17:e3000477. 

9. Cirnaru, M.D., Melis, C., Fanutza, T., Naphade, S., Tshilenge, K.N., Muntean, B.S., Martemyanov, K.A., Plotkin, J.L., Ellerby, L.M., Ehrlich, M.E.
Nuclear receptor Nr4a1 regulates striatal striosome development and dopamine D1 receptor signaling
eNeuro (2019) 6:ENEURO.0305-19.2019.

8. Muntean, B.S., Dao, M.T., Martemyanov, K.A.
Allostatic changes in cAMP system drive opioid induced adaptation in striatal dopamine signaling 
Cell Reports (2019) 29:946-960.e2. 

7. Wang, D., Stoveken, H.M., Zucca, S., Dao, M., Orlandi, C., Song, C., Masuho, I., Johnston, C., Opperman, K.J., Giles, A.C., Gill, M.S., Lundquist, E.A., Grill, B., Martemyanov, K.A.
Genetic behavioral screen identifies an orphan anti-opioid system
Science (2019) 365:1267-1273. 

6. Dunn, H.A., Orlandi, C., Martemyanov, K.A.
Beyond the ligand: extracellular and transcellular GPCR complexes in physiology and pharmacology
Pharmacological Reviews (2019) 71:503-519. 

5. Dunn, H.A., Zucca, S., Dao, M., Orlandi, C., Martemyanov, K.A.
ELFN2 is a postsynaptic cell adhesion molecule with essential roles in controlling group III mGluRs in the brain and neuropsychiatric behavior
Molecular Psychiatry (2019) 24:1902-1919.  

4. Song, C., Orlandi, C., Sutton, L.P., Martemyanov, K.A.
The signaling proteins GPR158 and RGS7 modulate excitability of L2/3 pyramidal neurons and control A-type potassium channel in the prelimbic cortex
Journal of Biological Chemistry (2019) 294:13145-13157. 

3. Xu, Z.X., Tan J.W., Hill, C.J., Xu, H., Ostrovskaya, O., Martemyanov, K.A., Xu, B.
Caspase-2 promotes AMPA receptor internalization and cognitive flexibility via mTORC2-AKT-GSK3b signaling
Nature Communications (2019) 10:3622. 

2. Itakura, T., Webster, A., Chintala, S.K., Wang, Y., Gonzalez, J.M. Jr., Tan, J.C., Vranka, J.A., Acott, T., Craft, C.M., Sibug Saber, M.E., Jeong, S., Stamer, W.D., Martemyanov, K.A., Fini, M.E.
GPR158 in the visual system: homeostatic role in regulation of intraocular pressure
Journal of Ocular Pharmacology and Therapeutics
(2019) 35:203-215.

1. Orlandi, C., Sutton, L.P., Muntean, B.S., Song, C., Martemyanov, K.A.
Homeostatic cAMP regulation by the RGS7 complex controls depression-related behaviors 
Neuropsychopharmacology (2019) 44:642-653. 


19. Patil, D.N., Rangarajan, E.S., Novick, S.J., Pascal, B.D., Kojetin, D.J., Griffin, P.R., Izard, T., Martemyanov, K.A.
Structural organization of a major neuronal G protein regulator, the RGS7-Gβ5-R7BP complex
(2018) 7:e42150. 

18. Ostrovskaya, Ol., Orlandi, C., Fajardo-Serrano, A., Young, S.M. Jr., Lujan, R., Martemyanov, K.A.
Inhibitory signaling to ion channels in hippocampal neurons is differentially regulated by alternative macromolecular complexes of RGS7
The Journal of Neuroscience (2018) 38:10002-10015. 

17. Condomitti, G., Wierda, K.D., Schroeder, A., Rubio, S.E., Vennekens, K.M., Orlandi C., Martemyanov, K.A., Gounko, N.V., Savas J.N., de Wit, J.
An input-specific orphan receptor GPR158-HSPG interaction organizes hippocampal mossy fiber-CA3 synapses
Neuron (2018) 100:201-215.e9. 

16. Orlandi, C., Omori, Y., Wang, Y., Cao, Y., Ueno, A., Roux, M.J., Condomitti, G., de Wit, J., Kanagawa, M., Furukawa, T., Martemyanov, K.A.
Transsynaptic binding of orphan receptor GPR179 to dystroglycan-pikachurin complex is essential for the synaptic organization of photoreceptors
 Cell Reports (2018) 25:130-145.e5. 

15. Song, C., Anderson, G.R., Sutton, L.P., Dao, M., Martemyanov, K.A.
Selective role of RGS9-2 in regulating retrograde synaptic signaling of indirect pathway medium spiny neurons in dorsal striatum
The Journal of Neuroscience (2018) 38:7120-7131. 

14. Masuho, I., Chavali, S., Muntean, B.S., Skamangas, N.K., Simonyan, K., Patil, D. N., Kramer, G.M., Ozelius, L., Babu, M.M., Martemyanov, K.A.
Molecular deconvolution platform to establish disease mechanisms by surveying GPCR signaling
Cell Reports (2018) 24:557-568.e5. 

13. Dunn, H.A., Patil, D.N., Cao, Y., Orlandi, C., Martemyanov, K.A.
Synaptic adhesion protein ELFN1 is a selective allosteric modulator of group III metabotropic glutamate receptors in trans
Proceedings of the National Academy of Sciences USA (2018) 115:5022-5027. 

12. Gulati, S., Masuho, I., Orban, T., Cai, Y., Pardon, E., Martemyanov, K.A., Kiser, P.D., Stewart, P.L., Ford, C.P., Steyaert, J., and Palczewski, K.
Targeting G protein-coupled receptor signaling at the G protein level with a selective nanobody inhibitor
Nature Communications (2018) 9:1996. 

11. Martemyanov, K.A., Garcia-Marcos, M.
Making useful gadgets with miniaturized G proteins
Journal of Biological Chemistry (2018) 293:7474-7475. 

10. Kulkarni, K., Xie, X., Fernandez de Velasco, EM., Anderson, A., Martemyanov, K.A., Wickman, K., Tolkacheva, E.G.
The influences of the M2R-GIRK4-RGS6 dependent parasympathetic pathway on electrophysiological properties of the mouse heart
PLos One (2018) 13:e0193798. 

9. Muntean, B.S., Patil, D.N., Madoux, F., Fossetta, J., Scampavia, L., Spicer, T.P., Martemyanov, K.A.
A high-throughput time-resolved fluorescence energy transfer assay to screen for modulators of RGS7/Gβ5/R7BP complex
Assay and Drug Development Technologies (2018) 16:150-161. 

8. Marcott, P.F., Gong, S., Donthamsetti, P., Grinnell, S.G., Nelson, M.N., Newman, A.H., Birnbaumer, L., Martemyanov, K.A., Javitch, J.A., Ford, C.P.
Regional heterogeneity of D2-receptor signaling in the dorsal striatum and nucleus accumbens
Neuron (2018) 98:575-587.e4. 

7. Spicer, T.P., Hubbs, C., Vaissiere, T., Collia, D., Rojas, C., Kilinc, M., Vick, K., Madoux, F., Baillargeon, P., Shumate, J., Martemyanov, K.A., Page, D.T., Puthanveettil, S., Hodder, P., Davis, R., Miller, C.A., Scampavia, L., Rumbaugh, G.
Improved scalability of neuron-based phenotypic screening assays for therapeutic discovery in neuropsychiatric disorders
Molecular Neuropsychiatry (2018) 3:141-150. 

6. Sarria, I., Cao, Y., Wang, Y., Ingram, N.T., Orland,i C., Kamasawa, N., Kolesnikov, A.V., Pahlberg, J., Kefalov, V.J., Sampath, A.P., Martemyanov, K.A.
LRIT1 modulates adaptive changes in synaptic communication of cone photoreceptors
Cell Reports (2018) 22:3562-3573. 

5. Sutton, L.P., Orlandi, C., Song, C., Oh, W.C., Muntean, B.S., Xie, K., Filippini, A., Xie, X., Satterfield, R., Yaeger, J.D.W., Renner, K.J., Young, S.M., Xu, B., Kwon, H., Martemyanov, K.A.
Orphan receptor GPR158 controls stress-induced depression
eLife (2018) 7:e33273. 

4. Anderson, A., Kulkarni, K., Marron Fernandez de Velasco, E., Carlblom, N., Xia, Z., Nakano, A., Martemyanov, K.A., Tolkacheva, E.G., Wickman, K.
Expression and relevance of the G protein-gated K+ channel in the mouse ventricle
Scientific Reports (2018) 8:1192. 

3. Qutob, N., Masuho, I., Alon, M., Emmanuel, R., Cohen, I., Di Pizio, A., Madore, J., Elkahloun, A., Ziv, T., Levy, R., Gartner, J.J., Hill, V.K., Lin, J.C., Hevroni, Y., Greenberg, P., Brodezki, A., Rosenberg, S.A., Koslo, M., Hayward, N.K., Admon, A., Niv MY, Scolyer RA, Martemyanov, K.A., Samuels Y.
RGS7 is recurrently mutated in melanoma and promotes migration and invasion of human cancer cells
Scientific Reports (2018) 8:653. 

2. Hauser, A.S., Chavali, S., Masuho, I., Jahn, L.J., Martemyanov, K.A., Gloriam, D.E., Babu, M.M.
Pharmacogenomics of GPCR drug targets
Cell (2018) 172:41-54.e19. 

1. Muntean, B.S., Zucca, S., MacMullen, C.M., Dao, M.T., Johnston, C., Iwamoto, H., Blakely, R.D., Davis, R.L., Martemyanov, K.A.
Interrogating the spatiotemporal landscape of neuromodulatory GPCR signaling by real-time imaging of cAMP in intact neurons and circuits
Cell Reports (2018) 22:255-268. 


6. Himmelreich, S., Masuho, I., Berry, J.A., MacMullen, C., Skamangas, N.K., Martemyanov, K.A., Davis, R.L.
Dopamine receptor DAMB signals via Gq to mediate forgetting in Drosophila
Cell Reports (2017) 21:2074-2081. 

5. Martemyanov, K.A., Sampath, A.P.
The transduction cascade in retinal ON-Bipolar cells: signal processing and disease
Annual Review of Vision Science (2017) 3:25-51. 

4. Carmon, K.S., Gong, X., Yi, J., Wu, L., Thomas, A., Moore, C.M., Masuho, I., Timson, D.J., Martemyanov, K.A., Liu, Q.J.
LGR5 receptor promotes cell-cell adhesion in stem cells and colon cancer cells via the IQGAP1-Rac1 pathway
Journal of Biological Chemistry (2017) 292:14989-15001. 

3. Neuillé, M., Cao, Y., Caplette, R., Guerrero-Given, D., Thomas, C., Kamasawa, N., Sahel, J.A., Hamel, C.P., Audo, I., Picaud, S., Martemyanov, K.A., Zeitz, C. 
LRIT3 Differentially affects connectivity and synaptic transmission of cones to ON- and OFF-Bipolar cells
Investigative Ophthalmology and Visual Science (2017) 58:1768-1778.

2. Wang, Y., Fehlhaber, K.E., Sarria, I., Cao, Y., Ingram, N.T., Guerrero-Given, D., Throesch, B., Baldwin, K., Kamasawa, N., Ohtsuka, T., Sampath, A.P., Martemyanov, K.A. 
The auxiliary calcium channel subunit α2δ4 is required for axonal elaboration, synaptic transmission, and wiring of rod photoreceptors
Neuron (2017) 93:1359-1374.e6. 

1. Lohmann, K., Masuho, I., Patil, D.N., Baumann, H., Hebert, E., Steinrücke, S., Trujillano, D., Skamangas, N.K., Dobricic, V., Hüning, I., Gillessen-Kaesbach, G., Westenberger, A., Savic-Pavicevic, D., Münchau, A., Oprea, G., Klein, C., Rolfs, A., Martemyanov, K.A.
Novel GNB1 mutations disrupt assembly and function of G protein heterotrimers and cause global developmental delay in humans
Human Molecular Genetics (2017) 26:1078-1086.


13. Aguado, C., Orlandi, C., Fajaro-Serrano, A., Gil-Minguez, M., Martemyanov, K.A., Lujan, R.
Cellular and subcellular localization of the RGS7/Gβ5/R7BP complex in the cerebellar cortex
Frontiers in Neuroanatomy
(2016) 10:114. 

12. Xie, K., Colgan, L.A., Dao, M.T., Muntean, B.S., Sutton, L.P., Orlandi, C., Boye, S.L., Boye, S.E., Shih, C.C., Li, Y., Xu, B., Smith, R.G., Yasuda, R., Martemyanov, K.A.
NF1 is a direct protein effector essential for opioid signaling to Ras in the striatum
Current Biology (2016) 26:2992-3003.

11. Victoria, N.C., Marron, Fernandez de Velasco, E., Ostrovskaya, O., Metzger, S., Xia, Z., Kotecki, L., Benneyworth, M.A., Zink, A.N., Martemyanov, K.A., Wickman, K.
G protein-gated K+ channel ablation in forebrain pyramidal neurons selectively impairs fear learning
Biological Psychiatry (2016) 80:796-806. 

10. Shamseldin, H.E., Masuho, I., Alenizi, A., Alyamani, S., Patil, D.N., Ibrahim, N., Martemyanov, K.A., Alkuraya, F.S.
GNB5 mutation causes a novel neuropsychiatric disorder featuring attention deficit hyperactivity disorder, severely impaired language development and normal cognition
Genome Biology (2016) 17:195. 

9. Sutton, L.P., Ostrovskaya, O., Dao, M., Xie, K., Orlandi, C., Smith, R., Wee, S., Martemyanov, K.A.
Regulator of G-protein signaling 7 regulates reward behavior by controlling opioid signaling in the striatum
Biological Psychiatry (2016) 80:235-245. 

8. Chen, Y., Palczewska, G., Masuho, I., Gao, S., Jin, H., Dong, Z., Gieser, L., Brooks, M.J., Kiser, P.D., Kern, T.S., Martemyanov, K.A., Swaroop, A., Palczewski, K.
Synergistically acting agonists and antagonists of G protein-coupled receptors prevent photoreceptor cell degeneration
Science Signaling (2016) 9:ra74. 

7. Masuho, I., Fang, M., Geng, C., Zhang, J., Jiang, H., Özgul, R.K., Yılmaz, D.Y., Yalnızoğlu, D., Yüksel, D., Yarrow, A., Myers, A., Burn, S.C., Crotwell, P.L., Padilla-Lopez, S., Dursun, A., Martemyanov, K.A., Kruer, M.C.
Homozygous GNAL mutation associated with familial childhood-onset generalized dystonia
Neurology Genetics (2016) 2:e78. 

6. Dos Santos, C.O., Masuho, I., da Silva-Júnior, F.P., Barbosa, E.R., Silva, S.M., Borges, V., Ferraz, H.B., Rocha, M.S., Limongi, J.C., Martemyanov, K.A., de Carvalho Aguiar, P.
Screening of GNAL variants in Brazilian patients with isolated dystonia reveals a novel mutation with partial loss of function
Journal of Neurology (2016) 263:665-668. 

5. Xu, Y., Orlandi, C., Cao, Y., Yang, S., Choi, C.I., Pagadala, V., Birnbaumer, L., Martemyanov, K.A., Vardi, N.
The TRPM1 channel in ON-bipolar cells is gated by both the α and the βγ subunits of the G-protein Go
Scientific Reports (2016) 6:20940. 

4. Tayou, J., Wang, Q., Jang, G.F., Pronin, A.N., Orlandi, C., Martemyanov, K.A., Crabb, J.W., Slepa,k V.Z.
Regulator of G-protein Signaling 7 (RGS7) can exist in a homo-oligomeric form that is regulated by Gαo and R7-binding protein
Journal of Biological Chemistry (2016) 291:9133-9147.

3. Sarria, I., Orlandi, C., McCall, M.A., Gregg, R.G., Martemyanov, K.A.
Intermolecular interaction between anchoring subunits specify subcellular targeting and function of RGS proteins in retina ON-bipolar neurons
The Journal of Neuroscience (2016) 36:2915-2925. 

2. Muntean, B.S., Martemyanov, K.A.
Association with the plasma membrane Is sufficient for potentiating catalytic activity of regulators of G protein signaling (RGS) proteins of the R7 subfamily
Journal of Biological Chemistry (2016);291:7195-7204. 

1. Salaga, M., Storr, M., Martemyanov, K.A., Fichna, J.
RGS proteins as targets in the treatment of intestinal inflammation and visceral pain: New insights and future perspectives
BioEssays (2016) 38:344-354.


7. Masuho, I., Ostrovskaya, O., Kramer, G.M., Jones, C.D., Xie, K., Martemyanov, K.A. 
Distinct profiles of functional discrimination among G proteins determine the actions of G protein-coupled receptors
Science Signaling (2015) 8:ra123.

6. Xie, K., Masuho, I., Shih, C.C., Cao, Y., Sasaki, K., Lai, C.W., Han, P.L., Ueda, H., Dessauer, C.W., Ehrlich, M.E., Xu, B., Willardson, B.M., Martemyanov, K.A.
Stable G protein-effector complexes in striatal neurons: mechanism of assembly and role in neurotransmitter signaling 
(2015) 4:e10451.


5. Cao, Y., Sarria, I., Fehlhaber, K.E., Kamasawa, N., Orlandi, C., James, K.N., Hazen, J.L., Gardner, M.R., Farzan, M., Lee, A., Baker, S., Baldwin, K., Sampath, A.P., Martemyanov, K.A
Mechanism for selective synaptic wiring of rod photoreceptors into the retinal circuitry and its role in vision
Neuron (2015) 87:1248-1260. 

4. Masuho, I., Martemyanov, K.A., Lambert, N.A.
Monitoring G protein activation in cells with BRET
Methods in Molecular Biology (2015) 1335:107-113. 

3. Neuillé, M., Morgans, C.W., Cao, Y., Orhan, E., Michiels, C., Sahel, J.A., Audo, I., Duvoisin, R.M., Martemyanov, K.A., Zeitz, C.
LRIT3 is essential to localize TRPM1 to the dendritic tips of depolarizing bipolar cells and may play a role in cone synapse formation
European Journal of Neuroscience (2015) 42:1966-1975.

2. Sarria, I., Pahlberg, J., Cao, Y., Kolesnikov, A.V., Kefalov, V.J., Sampath, A.P., Martemyanov, K.A.
Sensitivity and kinetics of signal transmission at the first visual synapse differentially impact visually-guided behavior
eLife (2015) 4:e06358. 

1. Orlandi, C., Xie, K., Masuho, I., Fajardo-Serrano, A., Lujan, R., Martemyanov, K.A.
Orphan receptor GPR158 is an allosteric modulator of regulator of G protein signaling 7 (RGS7) catalytic activity with essential role in dictating its expression and localization in the brain
Journal of Biological Chemistry (2015) 290:13622-13639. 


5. Martemyanov, K.A.
G protein signaling in the retina and beyond: the Cogan lecture
Investigative Ophthalmology and Visual Science (2014) 55:8201-07.

4. Ray, T.A., Heath, K.M., Hasan, N., Noel, J.M., Samuels, I.S., Martemyanov, K.A., Peachey, N.S., McCall, M.A., Gregg, R.G.
GPR179 Is required for high sensitivity of the mGluR6 signaling cascade in depolarizing bipolar cells
The Journal of Neuroscience (2014) 34:6334-6343. 

3. Ostrovskaya, O., Xie, K., Masuho, I., Fajardo-Serrano, A., Lujan, R., Wickman, K., Martemyanov, K.A.
RGS7/Gβ5/R7BP complex regulates synaptic plasticity and memory by modulating hippocampal GABABR-GIRK signaling
eLife (2014) 3:e02053. 

2. Kumar, K.R., Lohmann, K., Masuho, I., Miyamoto, R., Ferbert, A., Lohnau, T., Kasten, M., Hagenah, J., Brüggemann, N., Graf, J., Münchau, A., Kostic, V.S., Sue, C.M., Domingo, A.R., Rosales, R.L., Lee, L.V., Freimann, K., Westenberger, A., Mukai, Y., Kawarai, T., Kaj,i R., Klein, C., Martemyanov, K.A., Schmidt, A.
Mutations in GNAL: a novel cause of craniocervical dystonia
JAMA Neurology (2014) 71:490-494. 

1. Wydeven, N., Posokhova, E., Xia, Z., Martemyanov, K.A., Wickman, K.
RGS6, but not RGS4, is the dominant regulator of G protein signaling (RGS) modulator of the parasympathetic regulation of mouse heart rate
Journal of Biological Chemistry (2014) 289:2440-9. 


5. Posokhova, E., NG, D., Opel, A., Masuho, I., Tinker, A., Biesecker, L.G., Wickman, K., Martemyanov, K.A.
Essential role of the m2R-RGS6-IKACh pathway in controlling intrinsic heart rate variability
PLoS One (2013) 8:e76973. 

4. Orlandi, C., Cao, Y., Martemyanov, K.A. 
Orphan receptor GPR179 forms macromolecular complexes with components of metabotropic signaling cascade in retina ON-bipolar neurons
Investigative Ophthalmology and Visual Science (2013) 54:7153-7161. 

3. Masuho, I., Xie, K., Martemyanov, K.A. 
Macromolecular composition dictates receptor and G protein selectivity of regulator of G protein signaling (RGS) 7 and 9-2 protein complexes in living cells
Journal of Biological Chemistry (2013) 288:25129-25142. 

2. Fajardo-Serrano, A., Wydeven, N., Young, D., Watanabe, M., Shigemoto, R., Martemyanov, K.A., Wickman K., Lujan, R.
Association of Rgs7/Gβ5 complexes with Girk channels and GABAB receptors in hippocampal CA1 pyramidal neurons
Hippocampus (2013) 23:1231-1245.

1. Fuchs, T., Saunders-Pullman, R., Masuho, I., San Luciano, M., Raymond, D., Factor, S., Lang, A.E., Liang, T-W, Trosch, R.M., White, S., Ainehsazan, E., Herve, D., Sharma, N., Ehrlich, M.E., Martemyanov, K.A., Bressma, S.B., Ozelius, L.J.
Mutations in GNAL cause primary torsion dystonia
Nature Genetics (2013) 45:88-92.


5. Xie, K., Masuho, I., Brand, C., Dessauer, C.W., Martemyanov, K.A.
The complex of G protein regulator RGS9-2 and Gβ5 controls sensitization and signaling kinetics of type 5 adenylyl cyclase in the striatum
Science Signaling (2012) 5:ra63. 

4. Orlandi, C., Posokhova, E., Masuho, I., Ray, T.A., Hasan, N., Gregg, R.G., Martemyanov, K.A.
GPR158/179 regulate G protein signaling by controlling localization and activity of the RGS7 complexes
Journal of Cell Biology
(2012) 197:711-719. 

3. Cao, Y., Pahlberg, J., Sarria, I., Kamasaw,a N., Sampath, A.P., Martemyanov K.A.
Regulators of G protein signaling RGS7 and RGS11 determine the onset of the light response in ON bipolar neurons
Proceedings of the National Academy of Sciences USA (2012) 109:7905-7910. 

2. Xie, K., Ge, S., Collins, V.E., Haynes, C.L, Renner, K.J., Meisel, R.L., Lujan, R., Martemyanov, K.A.
Gβ5-RGS complexes are gatekeepers of hyperactivity involved in control of multiple neurotransmitter systems
Psychoparmacology (2012) 219:823-834. 

1. Terzi D., Cao Y., Agrimaki I., Martemyanov K.A., Zachariou V.
R7BP modulates opiate analgesia and tolerance but not withdrawal
Neuropsychopharmacology (2012) 37:1005-1012. 


5. Xie K. and Martemyanov K.A. 
Control of striatal signaling by g protein regulators
Frontiers in Neuroanatomy (2011) 5:49. 

4. Cao Y., Posokhova E., and Martemyanov K.A. 
TRPM1 forms complexes with nyctalopin in vivo and accumulates in postsynaptic compartment of ON-bipolar neurons in mGluR6-dependent manner
The Journal of Neuroscience (2011) 31:11521-11526. 

3. Gopalakrishna K.N., Doddapuneni K., Boyd K.K., Masuho I, Martemyanov K.A., and Artemyev N.O.
Interaction of transducin with uncoordinated 119 protein (UNC119): implications for the model of transducin trafficking in rod photoreceptors
Journal of Biological Chemistry (2011) 286:28954-28962.

2. Masuho I., Wakasugi-Masuho H., Posokhova E.N., Patton J.R., and Martemyanov K.A.
Type 5 G protein beta subunit (Gbeta5) controls the interaction of regulator of G protein signaling 9 (RGS9) with membrane anchors
Journal of Biological Chemistry (2011) 286:21806-21813. 

1. Posokhova E., Song H., Belcastro M., Higgins L., Bigley L.R., Michaud N.A., Martemyanov K.A., and Sokolov M.
Disruption of the chaperonin containing TCP-1 function in rods affects multiple protein networks and arrests outer segment morphogenesis
Molecular & Cellular Proteomics (2011) 10:M110.000570. 


9. Porter M.Y., Xie K., Pozharski E., Koelle M.R., and Martemyanov K.A.
A conserved protein interaction interface on the type 5 G protein beta subunit controls proteolytic stability and activity of R7 family regulator of G protein signaling proteins
Journal of Biological Chemistry (2010) 285:41100-41112. 

8. Posokhova E., Wydeven N., Allen K.L., Wickman K., and Martemyanov K.A.
RGS6/Gbeta5 complex accelerates IKACh gating kinetics in atrial myocytes and modulates parasympathetic regulation of heart rate
Circulation Research (2010) 107:1350-1354. 

7. Cao Y., Kolesnikov A.V., Masuho I., Kefalov V.J., and Martemyanov K.A.
Membrane anchoring subunits specify selective regulation of RGS9-Gbeta5 GAP complex in photoreceptor neurons
The Journal of Neuroscience (2010) 30:13784-13793. 

6. Xie K., Allen K.L., Kourrich S., Colón-Saez J., Thomas, M.J., Wickman K., and Martemyanov K.A.
Gbeta5 recruits R7 RGS proteins to GIRK channels to regulate the timing of neuronal inhibitory signaling
Nature Neuroscience (2010) 13:661-663. 

5. Panicker L.M., Zhang J.H., Posokhova E., Gastinger M.J., Martemyanov K.A., and Simonds W.F.
Nuclear localization of the G protein beta5/R7-regulator of G protein signaling protein complex is dependent on R7 binding protein
Journal of Neurochemistry (2010) 113:1101-1112. 

4. Posokhova E., Uversky V., and Martemyanov K.A.
Proteomic identification of Hsc70 as a mediator of RGS9-2 degradation by in vivo interactome analysis
Journal of Proteome Research (2010) 9:1510-1521. 

3. Roloff A.M., Anderson G.R., Martemyanov K.A., and Thayer S.A.
Homer 1a gates the induction mechanism for endocannabinoid-mediated synaptic plasticity
The Journal of Neuroscience (2010) 30:3072-3081 

2. Anderson G.R., Cao Y., Davidson S., Truong H.V., Pravetoni M., Thomas M.J., Wickman K., Giesler G.J. Jr., and Martemyanov K.A.
R7BP complexes with RGS9-2 and RGS7 in the striatum differentially control motor learning and locomotor responses to cocaine
Neuropsychopharmacology (2010) 35:1040-1050. 

1. Masuho I., Celver J., Kovoor A., and Martemyanov K.A.
Membrane anchor R9AP potentiates GTPase-accelerating protein activity of RGS11/Gbeta5 complex and accelerates inactivation of the mGluR6-Go signaling
Journal of Biological Chemistry (2010) 285:4781-4787. 


4. Anderson , G.R., Posokhova E., and Martemyanov K.A.
The R7 RGS protein family: multi-subunit regulators of neuronal G protein signaling
Cell Biochemistry and Biophysics (2009) 54:33-46. 

3. Martemyanov K.A. and Arshavsky V.Y.
Biology and functions of the RGS9 isoforms
Progress in Molecular Biology and Translational Science (2009) 86:205-207.

2. Cao Y., Masuho I., Okawa H., Xie K, Asami J., Kammermeier P., Furukawa T., Inoue Y., Sampath A.P., and Martemyanov K.A.
Retina-specific GTPase accelerator RGS11/Gbeta5S/R9AP is a constitutive heterotrimer selectively targeted to mGluR6 in ON-bipolar neurons
The Journal of Neuroscience (2009) 29:9301-9313.

1. Anderson G.R., Lujan R., and Martemyanov K.A.
Changes in striatal signaling induce remodeling of RGS complexes containing Gbeta5 and R7BP subunits
Molecular and Cellular Biology  (2009) 29:3033-3044. 


4. Martemyanov K.A., Krispel C.M., Lishko P.V., Burns M.E., and Arshavsky V.Y.
Functional comparison of RGS9 splice isoforms in a living cell
Proceedings of the National Academy of Sciences USA (2008) 105:20988-20993. 

3. Hooks S., Martemyanov K., and Zachariou V.
A role of RGS proteins in drug addiction
Biochemical Pharmacology (2008) 75:76-84. 

2. Kim H.J., Martemyanov K.A., and Thayer S.A.
Human immunodeficiency virus protein Tat induces synapse loss via a reversible process that is distinct from cell death
The Journal of Neuroscience (2008) 28:12604-12613. 

1. Cao Y., Song H., Okawa H., Sampath A.P., Sokolov M., and Martemyanov K.A.
Targeting of RGS7/G5 to the dendritic tips of ON-bipolar cells is independent of its association with membrane anchor R7BP
The Journal of Neuroscience (2008) 28:10443:10449. 


3. Anderson G.R., Lujan R., Semenov A., Pravetoni M., Posokhova E.N., Song J.H., Uversky V., Chen C-K., Wickman K., and Martemyanov K.A.
Expression and localization of RGS9-2/Gbeta5/R7BP complex in vivo is set by dynamic control of its constitutive degradation by cellular cysteine proteases
The Journal of Neuroscience (2007) 27:14117-14127.

2. Song J.H., Song H., Wensel T.G., Sokolov M., and Martemyanov K.A.
Localization and differential interaction of R7 RGS proteins with their membrane anchors R7BP and R9AP in neurons of vertebrate retina
Molecular and Cellular Neuroscience (2007) 35:311-319. 

1. Anderson G.R., Semenov A., Song J.H., Martemyanov K.A.
The membrane anchor R7BP controls the proteolytic stability of the striatal specific RGS protein, RGS9-2
Journal of Biological Chemistry (2007) 282:4772-4781. 


1. Song J.H., Waataja J.J., Martemyanov K.A.
Subcellular targeting of RGS9-2 is controlled by multiple molecular determinants on its membrane anchor, R7BP
Journal of Biological Chemistry (2006) 281:15361-15369.